Towards a definitive symptom structure of obsessive-compulsive disorder: a factor and network analysis of 87 distinct symptoms in 1366 individuals

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dc.authoridGüler, Ayşegül Selcen/0000-0002-7071-1743en_US
dc.authoridMataix-Cols, David/0000-0002-4545-0924en_US
dc.authoridFontenelle, Leonardo/0000-0001-9075-8226en_US
dc.authoridErdoğdu, Ayşe Burcu/0000-0002-7304-5109en_US
dc.authoriddo Rosario, Maria Conceição/0000-0002-9687-0072en_US
dc.authoridLeckman, James/0000-0002-3902-4478en_US
dc.authoridLazaro, Luisa/0000-0002-8425-5750en_US
dc.contributor.authorCervin, Matti
dc.contributor.authorMiguel, Euripedes C.
dc.contributor.authorGüler, Ayşegül Selcen
dc.contributor.authorFerrao, Ygor A.
dc.contributor.authorErdogdu, Ayşe Burcu
dc.contributor.authorLazaro, Luisa
dc.contributor.authorGokce, Sebla
dc.date.accessioned2024-07-12T21:37:33Z
dc.date.available2024-07-12T21:37:33Z
dc.date.issued2022en_US
dc.department[Belirlenecek]en_US
dc.description.abstractBackground The symptoms of obsessive-compulsive disorder (OCD) are highly heterogeneous and it is unclear what is the optimal way to conceptualize this heterogeneity. This study aimed to establish a comprehensive symptom structure model of OCD across the lifespan using factor and network analytic techniques. Methods A large multinational cohort of well-characterized children, adolescents, and adults diagnosed with OCD (N = 1366) participated in the study. All completed the Dimensional Yale-Brown Obsessive-Compulsive Scale, which contains an expanded checklist of 87 distinct OCD symptoms. Exploratory and confirmatory factor analysis were used to outline empirically supported symptom dimensions, and interconnections among the resulting dimensions were established using network analysis. Associations between dimensions and sociodemographic and clinical variables were explored using structural equation modeling (SEM). Results Thirteen first-order symptom dimensions emerged that could be parsimoniously reduced to eight broad dimensions, which were valid across the lifespan: Disturbing Thoughts, Incompleteness, Contamination, Hoarding, Transformation, Body Focus, Superstition, and Loss/Separation. A general OCD factor could be included in the final factor model without a significant decline in model fit according to most fit indices. Network analysis showed that Incompleteness and Disturbing Thoughts were most central (i.e. had most unique interconnections with other dimensions). SEM showed that the eight broad dimensions were differentially related to sociodemographic and clinical variables. Conclusions Future research will need to establish if this expanded hierarchical and multidimensional model can help improve our understanding of the etiology, neurobiology and treatment of OCD.en_US
dc.identifier.doi10.1017/S0033291720005437
dc.identifier.endpage3279en_US
dc.identifier.issn0033-2917
dc.identifier.issn1469-8978
dc.identifier.issue14en_US
dc.identifier.pmid33557980en_US
dc.identifier.scopus2-s2.0-85100757474en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3267en_US
dc.identifier.urihttps://doi.org/10.1017/S0033291720005437
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6846
dc.identifier.volume52en_US
dc.identifier.wosWOS:000785640400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofPsychological Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04188
dc.subjectObsessive-Compulsive Disorderen_US
dc.subjectSymptom Dimensionsen_US
dc.subjectHeterogeneityen_US
dc.subjectFactor Analysisen_US
dc.subjectNetwork Analysisen_US
dc.titleTowards a definitive symptom structure of obsessive-compulsive disorder: a factor and network analysis of 87 distinct symptoms in 1366 individualsen_US
dc.typeArticle
dspace.entity.typePublication

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