Is there any relationship between streptococcal infection and multiple sclerosis?

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dc.authorid0000-0003-2016-9965en_US
dc.contributor.authorTopkaya A.E.
dc.contributor.authorSahin S.
dc.contributor.authorAksungar F.B.
dc.contributor.authorBoru U.T.
dc.contributor.authorYildiz Z.
dc.contributor.authorSur H.
dc.date.accessioned2024-07-12T21:52:00Z
dc.date.available2024-07-12T21:52:00Z
dc.date.issued2007en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of uncertain etiology. Although the mechanisms of inducting autoimmunity by some of the infectious agents have been investigated, there is not yet enough research on streptococcal infections. Material/Methods: To understand the effect of past group A streptococcal infection on MS, antistreptolysin O (ASO) and antideoxyribonuclease B (ADNase B) were measured in 21 patients with relapsing-remitting MS and 21 healthy blood donors by nephelometric assay. Results: ADNase B levels in the patients with MS were found to be significantly higher than in the controls (p<0.001); however, ASO levels were similar in both groups. Conclusions: These findings indicate that a relationship between multiple sclerosis and streptococcal infections may exist, but to acquire a better understanding of the role of group A streptococci in the pathogenesis of multiple sclerosis, more studies with animal models are necessary. © Med Sci Monit, 2007.en_US
dc.identifier.endpageCR569en_US
dc.identifier.issn1234-1010
dc.identifier.issue12en_US
dc.identifier.pmid18049437en_US
dc.identifier.scopus2-s2.0-37249035123en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageCR567en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8338
dc.identifier.volume13en_US
dc.identifier.wosWOS:000251967000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02897
dc.subjectAdnase Ben_US
dc.subjectASOen_US
dc.subjectEtiologyen_US
dc.subjectGroup A streptococcien_US
dc.subjectMultiple sclerosisen_US
dc.titleIs there any relationship between streptococcal infection and multiple sclerosis?en_US
dc.typeArticle
dspace.entity.typePublication

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