Evaluation of platelet serotonin levels in migraine without aura [Aurasiz migrende trombosit serotonin düzeylerinin deg erlendirilmesi]

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dc.authorid0000-0003-2016-9965en_US
dc.authorid0000-0002-2887-9235en_US
dc.contributor.authorAyalp S.
dc.contributor.authorSahin Ş.
dc.contributor.authorBenli Aksungar F.
dc.contributor.authorKarsj¸dag S.
dc.date.accessioned2024-07-12T21:44:28Z
dc.date.available2024-07-12T21:44:28Z
dc.date.issued2012en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjectives: The relation between migraine and serotonin levels is not clear. Plasma serotonin levels in migraineurs were investigated in previous studies. However, in the current literature, it is stated that measurement of serotonin level in platelets is more reliable. Methods: Thirty female migraine without aura patients who were diagnosed according to the criteria of the International Headache Society and 20 healthy controls were enrolled in the study. The Hamilton depression scale (HAM-D) was applied to all subjects and those scoring 10 and above were not considered. Fasting venous blood samples were taken from subjects in the morning. Platelet rich and poor plasma were prepared. The samples were measured with high performance liquid chromatography and platelet serotonin concentration was calculated. Results: Our results suggest that migraineurs have significantly low platelet serotonin concentration compared to controls. The ratio of family history of migraine in the patient group was clearly higher than in controls. HAM-D scores were significantly higher in migraineurs than in the control group. Although there was a weak correlation between low serotonin levels and attack duration and number, there was no statistical significance. Conclusion: Our results suggest the role of heredity and low serotonin levels in the migraine pathogenesis. Even though all subjects enrolled in the study had scores under the depression level, HAM-D scores were higher in migraineurs than controls. This may indicate the presence of subclinical depression associated with low serotonin levels in migraineurs. Extensive studies including both serotonin and other markers duringpain and pain-free periods are needed.en_US
dc.identifier.doi10.5505/agri.2012.74946
dc.identifier.endpage122en_US
dc.identifier.issn1300-0012
dc.identifier.issue3en_US
dc.identifier.pmid22865518en_US
dc.identifier.scopus2-s2.0-84868099037en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://dx.doi.org/10.5505/agri.2012.74946
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7728
dc.identifier.volume24en_US
dc.identifier.wosWOS:000421302100004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.relation.ispartofAgrien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00128
dc.subjectMigraineen_US
dc.subjectPathophysiologyen_US
dc.subjectPlateleten_US
dc.subjectSerotoninen_US
dc.titleEvaluation of platelet serotonin levels in migraine without aura [Aurasiz migrende trombosit serotonin düzeylerinin deg erlendirilmesi]en_US
dc.typeArticle
dspace.entity.typePublication

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