Evaluation of paraoxonase-1 enzyme activity and oxidative stress relations in malignant mesothelioma cases

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dc.authorid0000-0003-3771-3277en_US
dc.contributor.authorTurgut Coşan, Didem
dc.contributor.authorAk, Güntülü
dc.contributor.authorÇolak, Emine
dc.contributor.authorDal, Aylin
dc.contributor.authorÖner, Çağrı
dc.contributor.authorSoyocak, Ahu
dc.contributor.authorÇolak, Ertuğrul
dc.contributor.authorGüneş, Hasan Veysi
dc.contributor.authorMetintaş, Muzaffer
dc.date.accessioned2024-07-12T21:03:34Z
dc.date.available2024-07-12T21:03:34Z
dc.date.issued2020en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBACKGROUND: Malignant pleural mesothelioma (MPM) is the most common cancer in the pleura and highly aggressive with a very poor prognosis. Asbestos, known as a carcinogenic mineral with fiber structures, is the main cause of MPM formation. Exposure to asbestos causes an increase in reactive oxygen species, deficiency of antioxidant enzyme levels, and DNA damage. As a result of asbestos pathogenesis, all of these changes cause pulmonary fibrosis, pleural diseases, and malignancies. The endogenous antioxidant paraoxonase-1 (PON-1) is a calcium-dependent esterase involved in the hydrolysis of lipid peroxides, and PON-1 has been shown to have protective properties in oxidative stress and inflammatory diseases in various studies. OBJECTIVE: The study aimed to examine the relationship of MPM with PON-1 enzyme activity and oxidative status using total oxidant status (TOS) and total antioxidant status (TAS). MATERIALS AND METHODS: The study population was formed of 33 retrospectively examined mesothelioma patients as MPM group and 33 age- and sex-matched healthy individuals as controls. PON-1 activity was measured spectrophotometrically by enzyme-linked immunosorbent assay method. Total antioxidant and oxidant status was determined using Rel Assay Diagnostics kit. Oxidative stress index (OSI) was estimated as the ratio of the TOS to the TAS levels. RESULTS: In the present study, PON-1, TOS, TAS, and OSI levels were adjusted by comorbidity and smoking. The results indicated that TOS and OSI of MPM patients increased compared to healthy controls (P < 0.001 for both). The results also demonstrated the decrease of PON-1 activity and TAS in MPM cases (P < 0.001, for both). CONCLUSION: These results suggested that oxidative stress occurring as a result of inhalation of asbestos fibers may reduce the level of PON-1.en_US
dc.identifier.citationTurgut Coşan, D., Ak, G., Çolak, E., Dal,A. vd. (2020). Evaluation of paraoxonase-1 enzyme activity and oxidative stress relations in malignant mesothelioma cases. Eurasian Journal of Pulmonology, Turkish Respiratory Society. 22(3), s. 153-157.en_US
dc.identifier.doi10.4103/ejop.ejop_78_19
dc.identifier.endpage157en_US
dc.identifier.issn2148-5402
dc.identifier.issue3en_US
dc.identifier.startpage153en_US
dc.identifier.trdizinid408787en_US
dc.identifier.urihttps://eurasianjpulmonol.com/article/56
dc.identifier.urihttps://doi.prg/10.4103/ejop.ejop_78_19
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3680
dc.identifier.volume22en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÖner, Çağrı
dc.language.isoenen_US
dc.publisherTurkish Respiratory Societyen_US
dc.relation.ispartofEurasian Journal of Pulmonologyen_US
dc.relation.publicationcategoryUlusal Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00831
dc.subjectMalignant pleural mesotheliomaen_US
dc.subjectoxidative stress indexen_US
dc.subjectparaoxonase?1en_US
dc.subjecttotal antioxidant statusen_US
dc.subjecttotal oxidant statusen_US
dc.titleEvaluation of paraoxonase-1 enzyme activity and oxidative stress relations in malignant mesothelioma casesen_US
dc.typeArticle
dspace.entity.typePublication

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