Long-term Effect of Colchicine Treatment in Preventing Urethral Stricture Recurrence After Internal Urethrotomy

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dc.authorid0000-0001-6537-866Xen_US
dc.contributor.authorSinanoglu, Orhun
dc.contributor.authorKurtulus, Fatih Osman
dc.contributor.authorAkgun, Feride Sinem
dc.date.accessioned2024-07-12T21:57:04Z
dc.date.available2024-07-12T21:57:04Z
dc.date.issued2018en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractPurpose: Urethral stricture, known as a scar formation leading to urethral lumen stricture in sub-epithelial tissue, is the most common late complication of transurethral prostate resection (TURP). The aim of study is to evaluate efficacy of colchicine treatment in preventing urethral stricture recurrence in patients after internal urethrotomy, and to determine whether colchicine treatment had a sustained effect in decreasing stricture recurrences in patients with concomitant diseases. Methods: Patient data with weak urine stream and/or voiding difficulty, and who had internal urethrotomy in Urology Department of Maltepe University Hospital between dates 01 January 2011 and December 2016 were collected. They were randomized to colchicine receiving, and non-receiving arms. Colchicine was given 1 g/day orally for two months, and primary efficacy point was defined as urethral stricture development in 3, 6, and 12 months after internal urethrotomy. Results: The study was conducted on 84 males with the mean age of 67.7 +/- 7.5 years. The mean ages of colchicine receivers and non-receivers were 68.2 +/- 7.6 and 67.1 +/- 7.6 years, respectively. Recurrence rate of urethral stricture was significantly lower in colchicine receivers (P = .044) than non-receivers. In overall evaluation, recurrence rate of urethral stricture was significantly low, if there was only one comorbidity (P = .006), but rates were significantly higher in presence of three (P = .010) and four (P = .040) comorbidities. No significant difference in recurrence rates was determined in patients without comorbidities or with two comorbidities (P > .05). Conclusion: Combination of oral colchicine with internal urethrotomy reduces recurrence rates of urethral stricture significantly.en_US
dc.identifier.endpage208en_US
dc.identifier.issn1735-1308
dc.identifier.issn1735-546X
dc.identifier.issue4en_US
dc.identifier.pmid29681046en_US
dc.identifier.scopus2-s2.0-85122229273en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8640
dc.identifier.volume15en_US
dc.identifier.wosWOS:000441478500010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherUROL & NEPHROL RES CTR-UNRCen_US
dc.relation.ispartofUROLOGY JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03971
dc.subjecturethral strictureen_US
dc.subjectcolchicineen_US
dc.subjectPeyronie's diseaseen_US
dc.subjectmaleen_US
dc.subjectfibrosisen_US
dc.subjectrecurrenceen_US
dc.titleLong-term Effect of Colchicine Treatment in Preventing Urethral Stricture Recurrence After Internal Urethrotomyen_US
dc.typeArticle
dspace.entity.typePublication

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