The relation between human Y chromosome microdeletions and sperm morphology

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dc.contributor.authorSevinç D.
dc.contributor.authorZehir A.
dc.contributor.authorBiricik A.
dc.contributor.authorSertyel S.
dc.contributor.authorKahraman S.
dc.contributor.authorGüney I.
dc.date.accessioned2024-07-12T21:51:50Z
dc.date.available2024-07-12T21:51:50Z
dc.date.issued2002en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: Recent investigations have supported the importance of Y chromosome microdeletions in male infertility. Besides different factors, sperm morphology is also a very important component of the clinical evaluation of male fertility potential. The aim of our study was to understand the relation between Y chromosome microdeletions and sperm morphology in different risk groups. Material and Methods: In this study, 34 infertile men were selected and examined in terms of sperm morphology and Y chromosome microdeletions. Semen analyses of the patients were performed by using Strict criteria and the samples were grouped according to the sperm abnormalities. Peripheral blood samples were examined for Y chromosome microdeletions by a multiplex polymerase chain reaction amplification of sequence-tagged sites (STS) of the Y chromosome. Results: The incidence of deletions in the group was 14.7% (5/34). The rates of Y chromosome microdeletion were 33.3% for megalohead, 33.3% for elongehead, 0% for roundhead, 100% for pinhead, 14.3% for severe teratozoospermia, 33.3% for severe neck abnormalities and 0% for tail-stump. Pregnancy could not be obtained from Y chromosome deleted cases. Conclusion: It seems that especially patients with sperm head and neck abnormality have increased microdeletion risk. It is suggested that a detailed sperm morphology examination and classification is needed to clarify the Y chromosome deletion-sperm morphology relation.en_US
dc.identifier.endpage232en_US
dc.identifier.issn1019-1941
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0141573145en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8322
dc.identifier.volume15en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofMarmara Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02831
dc.subjectMale infertilityen_US
dc.subjectSperm morphologyen_US
dc.subjectY chromosome microdeletionsen_US
dc.titleThe relation between human Y chromosome microdeletions and sperm morphologyen_US
dc.typeArticle
dspace.entity.typePublication

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