Age-related changes in tissue and plasma zinc levels: Modulation by exogenously administered melatonin

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dc.contributor.authorOeztuerk, Gueler
dc.contributor.authorAkbulut, K. Gonca
dc.contributor.authorAfrasyap, Lale
dc.date.accessioned2024-07-12T21:46:57Z
dc.date.available2024-07-12T21:46:57Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractMelatonin (MEL) is synthesized mainly in the pineal gland and derived from 5-hydroxytryptophan (5-HTP). Zinc (Zn) is one of the most important trace elements in the body. Zn and MEL levels are changed with aging. The aim of this study was to investigate the age-related changes of tissue and plasma Zn levels and effect of MEL administration on these parameters. Male wistar rats received for 3 weeks subcutaneous injection of MEL (10mg/kg). Kidney and pancreas Zn levels in old rats were significantly lower than middle-aged group. Spleen, small intestine, and plasma Zn levels were not different in middle-aged and old rats. On the other hand, MEL treatment increased Zn levels of small intestine and plasma in middle-aged rats. However, kidney, spleen, and pancreas Zn levels were unaffected by MEL treatment.en_US
dc.identifier.doi10.1080/03610730802271922
dc.identifier.endpage462en_US
dc.identifier.issn0361-073X
dc.identifier.issn1096-4657
dc.identifier.issue4en_US
dc.identifier.pmid18726755en_US
dc.identifier.scopus2-s2.0-50149098017en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage453en_US
dc.identifier.urihttps://dx.doi.org/10.1080/03610730802271922
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7972
dc.identifier.volume34en_US
dc.identifier.wosWOS:000258688600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofEXPERIMENTAL AGING RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00901
dc.titleAge-related changes in tissue and plasma zinc levels: Modulation by exogenously administered melatoninen_US
dc.typeArticle
dspace.entity.typePublication

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