Comparison of Bone Prefabrication with Vascularized Periosteal Flaps, Hydroxyapatite, and Bioactive Glass in Rats

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dc.authorid0000-0001-8054-7740en_US
dc.authorid0000-0001-8054-7740en_US
dc.contributor.authorErsoy, Burak
dc.contributor.authorBayramicli, Mehmet
dc.contributor.authorErcan, Feriha
dc.contributor.authorSirinoglu, Hakan
dc.contributor.authorTuran, Pinar
dc.contributor.authorNumanoglu, Ayhan
dc.date.accessioned2024-07-12T21:51:26Z
dc.date.available2024-07-12T21:51:26Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground Periosteal flaps possess osteoprogenitor cells and an osteoinductive potential that can be further augmented by combination with a biodegradable scaffold; therefore, various osteoconductive and osteostimulative biomaterials are frequently combined with periosteal flaps in studies of bone prefabrication. An experimental study was designed to determine and compare the contribution of bioactive glass and hydroxyapatite to osteoneogenesis in rats when combined with a periosteal flap. Materials and Methods In 60 Sprague Dawley rats, saphenous artery periosto-fasciocutaneous island flaps were transposed to abdomen. In group 1, the flap was left alone, in group 2, an empty artificial pocket made of Gore-Tex (W. L. Gore & Associates, Inc.; Flagstaff, AZ) was sutured onto the periosteal layer, and in groups 3 and 4, the pocket was filled with bioactive glass and hydroxyapatite, respectively. Following sampling for histological analysis, a 4-point scoring system was used to grade inflammatory cell infiltration, osteogenesis, angiogenesis, and cell migration into the bioactive material. Results The combination of the periosteal flap with any of the bioactive materials resulted in significantly higher percentages of animals exhibiting osteogenesis (80% in hydroxyapatite group and 93.3% in the bioactive glass group; p = 0.0000528) and angiogenesis. Comparison of the bioactive material groups revealed that a significantly higher proportion of animals in the bioactive glass group exhibited moderate or severe inflammation (80 vs. 20%; p = 0.002814). Conclusion Periosteal flaps prefabricated with hydroxyapatite or bioactive glass in rats exhibit osteogenic capacities that are not dependent on direct bone contact or proximity to vascular bony tissue. The innate capacity of the periosteal flap when utilized alone for osteoneogenesis was found to be rather insufficient.en_US
dc.identifier.doi10.1055/s-0034-1396770
dc.identifier.endpage299en_US
dc.identifier.issn0743-684X
dc.identifier.issn1098-8947
dc.identifier.issue4en_US
dc.identifier.pmid25785651en_US
dc.identifier.scopus2-s2.0-84939971438en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://dx.doi.org/10.1055/s-0034-1396770
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8264
dc.identifier.volume31en_US
dc.identifier.wosWOS:000353366900008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTHIEME MEDICAL PUBL INCen_US
dc.relation.ispartofJOURNAL OF RECONSTRUCTIVE MICROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02028
dc.subjecthydroxyapatiteen_US
dc.subjectbioactive glassen_US
dc.subjectperiosteumen_US
dc.subjectratsen_US
dc.subjectosteogenesisen_US
dc.titleComparison of Bone Prefabrication with Vascularized Periosteal Flaps, Hydroxyapatite, and Bioactive Glass in Ratsen_US
dc.typeArticle
dspace.entity.typePublication

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