Capsaicin Alters the Expression of Genetic and Epigenetic Molecules In Hepatocellular Carcinoma Cell

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dc.authoridÖNER, Çağrı/0000-0003-3771-3277en_US
dc.contributor.authorAtes, Beren
dc.contributor.authorOner, Cagri
dc.contributor.authorAkbulut, Zeynep
dc.contributor.authorColak, Ertugrul
dc.date.accessioned2024-07-12T21:37:43Z
dc.date.available2024-07-12T21:37:43Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractCapsaicin is a natural product which is extracted from pepper and has the potential to be used in cancer treatment because of its anti- proliferative effects. The aim of the study was to determine the effect of capsaicin on the hepatocellular carcinoma cell proliferation and the expressions of related genetic markers as Ki-67, PI3K/AKT/mTOR and epigenetic markers as miR-126 and piR-Hep-1. The inhibitory concentration of capsaicin in HepG2 cells was determined. piR-Hep-1 and miR-126 expressions and Ki-67, PI3K, AKT and mTOR gene expressions were examined by RT-PCR. The inhibitory concentration of capsaicin for HepG2 cells was 200 nM and the decreased proliferation was observed at 24th hour. As epigenetic markers, an up regulation of miR-126 and down regulation of piR-Hep-1 expression were determined after treatment. Moreover, Ki-67, PI3K and mTOR gene expressions decreased while AKT gene expression increased after the treatment (p<0.001). According to the obtained data, capsaicin has an impact on proliferation both genetically and epigenetically. Furthermore, treatment of capsaicin effects miR-126 and piR-Hep-1 expressions which effect carcinogenesis in different way. Moreover, there are some clues which indicate that these two small non-coding RNA might affect each other and share the same target molecules post-transcriptionally.en_US
dc.description.sponsorship2209-A Program of The Scientific and Technological Research Council of Turkey (TUBITAK)en_US
dc.description.sponsorshipThis study was funded by 2209-A Program of The Scientific and Technological Research Council of Turkey (TUBITAK) .en_US
dc.identifier.doi10.22088/IJMCM.BUMS.11.3.236
dc.identifier.endpage243en_US
dc.identifier.issn2251-9637
dc.identifier.issn2251-9645
dc.identifier.issue3en_US
dc.identifier.pmid37605741en_US
dc.identifier.scopus2-s2.0-85170266187en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage236en_US
dc.identifier.urihttps://doi.org/10.22088/IJMCM.BUMS.11.3.236
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6908
dc.identifier.volume11en_US
dc.identifier.wosWOS:001070823800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCellular & Molecular Biology Research Centeren_US
dc.relation.ispartofInternational Journal of Molecular And Cellular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04250
dc.subjectCapsaicinen_US
dc.subjectMir-126en_US
dc.subjectPir-Hep-1en_US
dc.subjectPi3k/Akt/Mtor Signallingen_US
dc.titleCapsaicin Alters the Expression of Genetic and Epigenetic Molecules In Hepatocellular Carcinoma Cellen_US
dc.typeArticle
dspace.entity.typePublication

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