Classical xanthinuria: A rare cause of pediatric urolithiasis [Klasik ksantinüri: Çocuklarda ürolitiyazisin nadir bir nedeni]

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dc.contributor.authorAkinci N.
dc.contributor.authorÇakil A.
dc.contributor.authorÖner A.
dc.date.accessioned2024-07-12T21:54:03Z
dc.date.available2024-07-12T21:54:03Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractXanthine dehydrogenase catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid in the final two steps of purine degradation. Xanthine oxidase deficiency is an uncommon cause of pediatric urinary stone formation and classical xanthinuria. A ten-month-old boy presented with a seven-month history of nausea, vomiting, discomfort during urination, gross hematuria and passage of stones. His renal and liver function tests and electrolytes were normal, but serum and urine uric acid were undetectable. Ultrasonographic evaluation of the urinary tract revealed the presence of multiple bilateral renal stones. The renal stones were analyzed using an X-ray diffractometer and were found to be composed of hypoxanthinexanthine. High fluid intake, alkalinization and a low-purine diet were prescribed, and extracorporeal shock wave lithotripsy was performed. Recurrent renal stone formation was not observed during 18 months of follow-up. This case is reported to highlight the nature of this rare condition. © 2013 by Turkish Association of Urology.en_US
dc.identifier.doi10.5152/tud.2013.066
dc.identifier.endpage276en_US
dc.identifier.issn1300-5804
dc.identifier.issue4en_US
dc.identifier.pmid26328123en_US
dc.identifier.startpage274en_US
dc.identifier.urihttps://dx.doi.org/10.5152/tud.2013.066
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8561
dc.identifier.volume39en_US
dc.identifier.wosWOS:000420579800012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofTurk Uroloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03682
dc.subjectUrolithiasisen_US
dc.subjectXanthine dehydrogenaseen_US
dc.subjectXanthinuriaen_US
dc.titleClassical xanthinuria: A rare cause of pediatric urolithiasis [Klasik ksantinüri: Çocuklarda ürolitiyazisin nadir bir nedeni]en_US
dc.typeArticle
dspace.entity.typePublication

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