Effects of fluoxetine on ethanol withdrawal syndrome in rats

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dc.authorid0000-0002-6423-4207en_US
dc.authorid0000-0002-0021-8400en_US
dc.contributor.authorUzbay, IT
dc.contributor.authorSaglam, E
dc.contributor.authorKayir, H
dc.contributor.authorCelik, T
dc.contributor.authorBeyazyurek, M
dc.date.accessioned2024-07-12T21:51:20Z
dc.date.available2024-07-12T21:51:20Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe present study was designed to investigate the effects of fluoxetine, a selective serotonin reuptake inhibitor, on ethanol withdrawal syndrome in rats. Adult male Wistar rats (218-255 g) were subjects. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 21 days. Control rats were pair fed an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. Fluoxetine (2.5, 5 and 10 mg/kg) and saline were injected to rats intraperitoneally just before ethanol withdrawal. After 2nd, 4th and 6th hour of ethanol withdrawal, rats were observed for 5 min, and withdrawal signs that included locomotor hyperactivity, agitation, stereotyped behavior, wet dog shakes and tremor were recorded or rated. A second series of injections was given at 6 h after the first one, and subjects were then tested for audiogenic, seizures. Fluoxetine produced some dose-dependent and significant inhibitory effects on all the signs of ethanol withdrawal during ethanol withdrawal period. Our results suggest that acute fluoxetine treatment has some beneficial effects on ethanol withdrawal in rats. Thus, this drug may be useful for treatment of ethanol withdrawal syndrome. (C) 2003 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpsychires.2003.11.007
dc.identifier.endpage450en_US
dc.identifier.issn0022-3956
dc.identifier.issue4en_US
dc.identifier.pmid15203297en_US
dc.identifier.scopus2-s2.0-2942555445en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpsychires.2003.11.007
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8258
dc.identifier.volume38en_US
dc.identifier.wosWOS:000223211600011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofJOURNAL OF PSYCHIATRIC RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02021
dc.subjectethanol withdrawal syndromeen_US
dc.subjectethanol dependenceen_US
dc.subjectfluoxetineen_US
dc.subjectrat(s)en_US
dc.titleEffects of fluoxetine on ethanol withdrawal syndrome in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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