Bronchial hyperreactivity and airway wall thickening in obstructive sleep apnea patients

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dc.authorid0000-0003-3311-3338en_US
dc.authorid0000-0001-7360-8269en_US
dc.authorid0000-0002-5539-2502en_US
dc.contributor.authorSariman, Nesrin
dc.contributor.authorLevent, Ender
dc.contributor.authorCubuk, Rahmi
dc.contributor.authorYurtlu, Sirin
dc.contributor.authorAksungar, Fehime Benli
dc.date.accessioned2024-07-12T21:53:22Z
dc.date.available2024-07-12T21:53:22Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractHypoxia/reoxygenation episodes in obstructive sleep apnea (OSA) results in the alteration of the oxidative balance, leading to the development of inflammation. Airway wall thickening and inflammatory changes are suggested as a primary cause of the airway hyperresponsiveness in asthmatics. Bronchial hyperreactivity (BH) may also occur in patients with OSA. We investigated the presence of BH and airway wall thickness in OSA and correlations with inflammatory markers. Sixteen OSA patients and ten controls without allergic diseases were prospectively studied. Plasma pro-B-type natriuretic peptide (pro-BNP), fibrinogen, D-dimer, alpha 1-antitrypsin, and high-sensitive C-reactive protein levels were measured. Airway wall thickness was evaluated with high-resolution CT, and BH was assessed by giving each subject a methacholine challenge test. In OSA patients, bronchial wall thickness, fibrinogen, D-dimer, alpha 1-antitrypsin, high sensitive C-reactive protein, and pro-BNP levels were significantly greater than those in control subjects. Among the 16 patients, three had BH on methacholine challenge. Bronchial wall thickness(mm) was positively correlated with apnea-hypopnea index (AHI: number of apneas + hypopneas/hour of sleep), BMI, respiratory arousal index, nocturnal oxygen desaturation (NOD) duration (time in minutes with a nocturnal arterial oxygen saturation of < 90% during sleep), and alpha 1-antitrypsin levels. NOD duration also correlated with pro-BNP and fibrinogen levels. In OSA patients, walls of central airways were thicker than normal subjects. BH may have occurred in OSA patients. NOD duration correlated with inflammatory parameters and oxygen desaturation index 3% had an effect on the thickness of bronchial walls. But overall, AHI was found to be the only independent predictor of bronchial wall thickness.en_US
dc.identifier.doi10.1007/s11325-010-0387-7
dc.identifier.endpage350en_US
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.issue3en_US
dc.identifier.pmid20607424en_US
dc.identifier.scopus2-s2.0-80054887263en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage341en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11325-010-0387-7
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8489
dc.identifier.volume15en_US
dc.identifier.wosWOS:000295529600011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofSLEEP AND BREATHINGen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03425
dc.subjectAirway wall thickeningen_US
dc.subjectBronchial hyperreactivityen_US
dc.subjectObstructive sleep apneaen_US
dc.subjectHigh-resolution computerized tomographyen_US
dc.titleBronchial hyperreactivity and airway wall thickening in obstructive sleep apnea patientsen_US
dc.typeArticle
dspace.entity.typePublication

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