Weekend warrior exercise model for protection from chronic mild stress-induced depression and ongoing cognitive impairment

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dc.authoridŞahin, ali/0000-0001-5594-1551en_US
dc.contributor.authorÇantalı Öztürk, Çigdem
dc.contributor.authorAtaoğlu, Serra Nur
dc.contributor.authorArvas, Ayşenur
dc.contributor.authorTokol, Hamide
dc.contributor.authorYaprak, Havva
dc.contributor.authorGurel, Sumeyra
dc.contributor.authorLevent, Hilal Nisva
dc.date.accessioned2024-07-12T21:37:50Z
dc.date.available2024-07-12T21:37:50Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractWe aim to investigate the role and biological mechanisms of the weekend warrior (WW) exercise model on depression-induced rats in comparison to the continuous exercise (CE) model. Sedentary, WW, and CE rats were subjected to chronic mild stress (CMS) procedure. CMS and exercise protocols continued for six weeks. Anhedonia was evaluated by sucrose preference, depressive behavior by Porsolt, cognitive functions by object recognition and passive avoidance, and anxiety levels by open field and elevated plus maze. After behavioral assessments, brain tissue myeloperoxidase (MPO) activity, malondialdehyde (MDA) levels, superoxide dismutase and catalase activities and GSH content, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-1 beta, cortisol and brain-derived neurotrophic factor levels and histological damage was assessed. CMS-induced depression-like outcomes with increases in anhedonia and decreases in cognitive measures that are rescued with both exercise models. The increased immobilization time in the Porsolt test was decreased with only WW. Exercise also normalized the suppression of antioxidant capacity and MPO increase induced by CMS in both exercise models. MDA levels also declined with both exercise models. Anxiety-like behavior, cortisol levels, and histological damage scores were exacerbated with depression and improved by both exercise models. TNF-alpha levels were depleted with both exercise models, and IL-6 only with WW. WW was as protective as CE in CMS-induced depression-like cognitive and behavioral changes via suppressing inflammatory processes and improving antioxidant capacity.en_US
dc.description.sponsorshipMaltepe University Scientific Research Committeeen_US
dc.description.sponsorshipThe work was supported by the Maltepe University Scientific Research Committee.en_US
dc.identifier.doi10.55782/ane-2023-002
dc.identifier.endpage24en_US
dc.identifier.issn0065-1400
dc.identifier.issn1689-0035
dc.identifier.issue1en_US
dc.identifier.pmid37078810en_US
dc.identifier.scopus2-s2.0-85153412122en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.55782/ane-2023-002
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6957
dc.identifier.volume83en_US
dc.identifier.wosWOS:001159271800003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherNencki Inst Experimental Biologyen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04299
dc.subjectWeekend Warrioren_US
dc.subjectExerciseen_US
dc.subjectDepressionen_US
dc.subjectCognitive Functionen_US
dc.subjectContinuous Exerciseen_US
dc.titleWeekend warrior exercise model for protection from chronic mild stress-induced depression and ongoing cognitive impairmenten_US
dc.typeArticle
dspace.entity.typePublication

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