Hemostasis vs. epidural fibrosis?: A comparative study on an experimental rat model of laminectomy
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TERMEDIA PUBLISHING HOUSE LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: The aim of this study was to evaluate the histopathological and biochemical impact and effectiveness of two hemostatic agents, Ankaferd blood stopper (ABS) and Microporous Polysaccharide Hemospheres (MPH), on epidural fibrosis in an experimental rat laminectomy model. Material and methods: Twenty adult Wistar albino rats were divided into MPH-treated (n = 6), ABS-treated (n = 6) and control (n = 8) groups. Laminectomy of the lumbar spine was performed in all animals and treatment groups were exposed to MPH and ABS while closure was applied in control group as per usual. Epidural fibrosis was evaluated in all groups macroscopically, histopathologically, biochemically and with electron microscopy four weeks later. Results: Statistically, it was found that MPH-treated group had significantly less epidural fibrosis compared to ABS-treated and control groups. Conclusion: We compared two hemostatic agents for their propensity to cause adhesions in the present study. Our results show that MPH significantly reduces epidural scar formation and dural adhesion in a rat model of laminectomy while ABS increases postoperative fibrosis. (C) 2016 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.
Açıklama
Anahtar Kelimeler
Epidural fibrosis, Hemostasis, Laminectomy, Rats
Kaynak
NEUROLOGIA I NEUROCHIRURGIA POLSKA
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
50
Sayı
5
