Rapid Ischemic Preconditioning with a Short Reperfusion Time Prevents Delayed Paraplegia in a Rabbit Model

Basit Öğe Kaydı
dc.authorid0000-0001-5427-550Xen_US
dc.contributor.authorOzkokeli, Mehmet
dc.contributor.authorEs, Mehmet Ugur
dc.contributor.authorFilizcan, Ugur
dc.contributor.authorUgurlucan, Murat
dc.contributor.authorSasmazel, Ahmet
dc.contributor.authorTataroglu, Cenk
dc.date.accessioned2024-07-12T21:47:17Z
dc.date.available2024-07-12T21:47:17Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Surgery for thoracic and thoracoabdominal aortic aneurysms can be complicated by a significant incidence of neurogenic deficits due to spinal cord ischemia. In this study, we investigated whether ischemic preconditioning (IPC) improves neurologic outcome in a rabbit model. Methods: Forty rabbits underwent infrarenal aortic occlusion. The IPC group (n = 20) had 10 minutes of aortic occlusion to induce spinal cord ischemia, 40 minutes of reperfusion, and 30 minutes of ischemia, whereas the control group (n = 20) had only 30 minutes of ischemia. Tarlov scoring (0, paraplegia; 4, normal) was used to evaluate neurologic functions 7 days later, and spinal cord segments (L4-L6) were stained with hematoxylin and eosin for histologic evaluation. Results: Complete paraplegia (grade 0) occurred in 15 (75%) of the 20 control animals, whereas in the IPC group, 13 (65%) of 20 animals were completely normal (grade 4) (P < .05). Conclusion: IPC is beneficial for protecting against neurologic damage after transient aortic occlusion in a rabbit model; however, the protective mechanisms are not clear.en_US
dc.identifier.doi10.1532/HSF98.20111039
dc.identifier.endpageE321en_US
dc.identifier.issn1098-3511
dc.identifier.issue5en_US
dc.identifier.pmid21997656en_US
dc.identifier.scopus2-s2.0-80054841184en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE317en_US
dc.identifier.urihttps://dx.doi.org/10.1532/HSF98.20111039
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8028
dc.identifier.volume14en_US
dc.identifier.wosWOS:000296341700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherFORUM MULTIMEDIA PUBLISHING, LLCen_US
dc.relation.ispartofHEART SURGERY FORUMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01182
dc.titleRapid Ischemic Preconditioning with a Short Reperfusion Time Prevents Delayed Paraplegia in a Rabbit Modelen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu