Levels of soluble intercellular adhesion molecule-1 and tumor necrosis factor-? in the sera of young children with persistent or recurrent wheeze

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dc.contributor.authorCakir, M.
dc.contributor.authorÇetinkaya, Feyzullah
dc.date.accessioned2024-07-12T21:38:03Z
dc.date.available2024-07-12T21:38:03Z
dc.date.issued2009en_US
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: Intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor-alfa (TNF-alpha) are important inflammatory mediators in asthma and other allergic diseases. But their role is not clear in young children with wheezing. This study analyzed plasma levels of soluble ICAM-1 (sICAM-1) and TNF-alpha in young children with persistent or recurrent wheeze. Materials and Methods: Thirty children (aged 424 months) with acute wheezing were recruited from pediatric outpatients of our hospital. The diagnosis of acute wheezing episodes was based on symptoms and the children with known causes of wheezing were excluded from the study. The study also consisted of 30 age-matched controls who admitted for anemia or mild trauma but had never wheezed before. Results: In wheezy patients soluble ICAM-1 and TNF-alpha levels were significantly higher (815 +/- 296 ng/mL and 253 +/- 207 pg/mL respectively) during symptomatic period than symptom-free period (609 +/- 280 ng/mL and 100 +/- 86 pg/mL respectively) and both of first and second levels of these markers were higher in patients than in controls. Conclusion: These results show that sICAM-1 and TNF-alpha levels increase in sera of children with wheezing and measurement of these molecules may be useful to show the presence and activation of airway inflammation in young wheezy children.en_US
dc.identifier.endpage110en_US
dc.identifier.issn1308-9234
dc.identifier.issue2en_US
dc.identifier.startpage106en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7045
dc.identifier.volume7en_US
dc.identifier.wosWOS:000420819100006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.ispartofAstim Allerji Immunolojien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04436
dc.subjectWheezingen_US
dc.subjectIntercellular Adhesion Molecule-1en_US
dc.subjectTumor Necrosis Factoren_US
dc.subjectAlphaen_US
dc.subjectAsthmaen_US
dc.titleLevels of soluble intercellular adhesion molecule-1 and tumor necrosis factor-? in the sera of young children with persistent or recurrent wheezeen_US
dc.typeArticle
dspace.entity.typePublication

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