Nitric oxide levels during erythroid differentiation in K562 cell line

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dc.contributor.authorKüçükkaya B.
dc.contributor.authorÖztürk G.
dc.contributor.authorYalçintepe L.
dc.date.accessioned2024-07-12T21:47:42Z
dc.date.available2024-07-12T21:47:42Z
dc.date.issued2006en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractNitric oxide (NO) is endogenous mediator of numerous physiological processes that range from regulation of cardiovascular function and neurotransmission to antipathogenic and tumoricidal responses. This study was designed to investigate the possible role of NO during erythroid differentiation in K562 erythroleukemia cells. The chronic myelogenous leukemia (K562) cell line can be triggered in culture to differentiate along the erythrocytic pathway, in response to a variety of stimulatory agents. In this study, K562 cells were induced to synthesize hemoglobin by hemin. We investigated NOx (nitrate+nitrite) levels in uninduced (control) and hemin-induced K562 cell lysates during erythroid differentiation. Our results showed that NO levels decreased significantly on fourth and sixth day both in hemin-induced and control cells; the decrease was, however, more in hemin-induced group than in control group.en_US
dc.identifier.endpage253en_US
dc.identifier.issn0301-1208
dc.identifier.issue4en_US
dc.identifier.pmid17133771en_US
dc.identifier.scopus2-s2.0-33846323657en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8063
dc.identifier.volume43en_US
dc.identifier.wosWOS:000240011500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofIndian Journal of Biochemistry and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01245
dc.subjectErythroid differentiationen_US
dc.subjectHeminen_US
dc.subjectK562 cell lineen_US
dc.subjectNitric oxideen_US
dc.titleNitric oxide levels during erythroid differentiation in K562 cell lineen_US
dc.typeArticle
dspace.entity.typePublication

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