Intercellular Adhesion Molecule-1 Lys469Glu Polymorphism, Systemic Redox Homeostasis and Gestational Diabetes Mellitus in Pregnant Women

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dc.authorid0000-0001-6298-5026en_US
dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorYanar, Karolin
dc.contributor.authorAydin, Seval
dc.contributor.authorSimsek, Bahadir
dc.contributor.authorYaylim, Ilhan
dc.contributor.authorTuran, Saime
dc.contributor.authorSitar, Mustafa Erinc
dc.contributor.authorCacina, Canan
dc.contributor.authorKucukhuseyin, Ozlem
dc.contributor.authorTuten, Abdullah
dc.contributor.authorCakatay, Ufuk
dc.contributor.authorBenian, Ali
dc.date.accessioned2024-07-12T21:45:24Z
dc.date.available2024-07-12T21:45:24Z
dc.date.issued2019en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjectives: Intercellular adhesion molecule-1 (ICAM-1) plays an important role in endothelial function. Hyperglycemia-induced impaired redox status is 1 of the well-known pathophysiologic characteristics of gestational diabetes mellitus (GDM), and it plays a crucial role in the causes of disease. Our aim was to clarify any possible relationship between the ICAM-1 Lys469Glu polymorphism and systemic redox status in women with and without GDM. Also, we investigated whether this polymorphism could be associated with a change for better or worse as evidenced by clinical and redox biomarkers. Methods: The ICAM-1 polymorphism statuses of 89 pregnant women without GDM and 53 pregnant women with GDM were found. Stratifying patients based on GDM and polymorphism status, we investigated various redox homeostasis markers. The independent t test was used. Results: Significantly higher systemic oxidative damage and diminished antioxidant defense were found in pregnant women with GDM. Also, results showed that whether pregnant women were carrying the Lys469Glu polymorphism or not did not seem to be associated with significant differences, as evidenced by comparable systemic oxidative damage. Conclusions: Although no significant difference was observed between genotypes, the oxidative damage observed in patients with GDM warrants earlier screening and management in the light of new evidence. (C) 2018 Canadian Diabetes Association.en_US
dc.description.sponsorshipIstanbul University, Republic of Turkey [57727, 29137]en_US
dc.description.sponsorshipThis work was supported by grants from the Istanbul University, Republic of Turkey (#57727, 29137).en_US
dc.identifier.doi10.1016/j.jcjd.2018.07.003
dc.identifier.endpage+en_US
dc.identifier.issn1499-2671
dc.identifier.issue3en_US
dc.identifier.pmid30297297en_US
dc.identifier.scopus2-s2.0-85054518538en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jcjd.2018.07.003
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7830
dc.identifier.volume43en_US
dc.identifier.wosWOS:000462623200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofCANADIAN JOURNAL OF DIABETESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00470
dc.subjectantioxidantsen_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectintercellular adhesion molecule-1en_US
dc.subjectlipid peroxidationen_US
dc.subjectLys469Glu polymorphismen_US
dc.subjectredox homeostasisen_US
dc.titleIntercellular Adhesion Molecule-1 Lys469Glu Polymorphism, Systemic Redox Homeostasis and Gestational Diabetes Mellitus in Pregnant Womenen_US
dc.typeArticle
dspace.entity.typePublication

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