Increased Beta Frequency (15-30 Hz) Oscillatory Responses in Euthymic Bipolar Patients Under Lithium Monotherapy

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dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0002-8514-0576en_US
dc.authorid0000-0003-0150-5476en_US
dc.contributor.authorTan, Devran
dc.contributor.authorOzerdem, Aysegul
dc.contributor.authorGuntekin, Bahar
dc.contributor.authorAtagun, M. Ilhan
dc.contributor.authorTulay, Elif
dc.contributor.authorKaradag, Figen
dc.contributor.authorBasar, Erol
dc.date.accessioned2024-07-12T21:45:45Z
dc.date.available2024-07-12T21:45:45Z
dc.date.issued2016en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe effect of lithium on neurocognition is not still fully explored. Brain oscillatory activity is altered in bipolar disorder. We aimed to assess the oscillatory responses of euthymic bipolar patients and how they are affected by lithium monotherapy. Event-related oscillations in response to visual target stimulus during an oddball paradigm in 16 euthymic drug-free and 13 euthymic lithium-treated bipolar patients were compared with 16 healthy controls. The maximum peak-to-peak amplitudes were measured for each subject's averaged beta (15-30 Hz) responses in the 0- to 300-ms time window over frontal (F3, Fz, F4), central (C3, Cz, C4), temporal (T7, T8), temporo-parietal (TP7, TP8), parietal (P3, Pz, P4), and occipital (O1, Oz, O2) areas. Patients under lithium monotherapy had significantly higher beta responses to visual target stimuli than healthy controls (P = .017) and drug-free patients (P = .015). The increase in beta response was observed at all electrode locations, however, the difference was statistically significant for the left (T7; P = .016) and right (T8; P = .031) temporal beta responses. Increased beta responses in drug-free patients and further significant increase in lithium-treated patients may be indicative of a core pathophysiological process of bipolar disorder and how it is affected by lithium. Whether the finding corresponds to lithium's corrective effect on the underlying pathology or to its neurocognitive side effect remains to be further explored. In either case, the finding is a sign that the oscillatory activity may be useful in tracking medication effect in bipolar disorder.en_US
dc.description.sponsorshipMental Health/Developmental Disabilities Research Award at Children's Hospital, Boston (NIH HHS/United States) [43TW05807/TW/FIC]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Mental Health/Developmental Disabilities Research Award at the Children's Hospital, Boston (43TW05807/TW/FIC NIH HHS/United States, Dr Kerim Munir, Principal Investigator).en_US
dc.identifier.doi10.1177/1550059414561056
dc.identifier.endpage95en_US
dc.identifier.issn1550-0594
dc.identifier.issn2169-5202
dc.identifier.issue2en_US
dc.identifier.pmid25465436en_US
dc.identifier.scopus2-s2.0-84961692481en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://dx.doi.org/10.1177/1550059414561056
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7854
dc.identifier.volume47en_US
dc.identifier.wosWOS:000373081100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.ispartofCLINICAL EEG AND NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00513
dc.subjectbipolar disorderen_US
dc.subjecteuthymiaen_US
dc.subjectlithiumen_US
dc.subjectbrain oscillationsen_US
dc.subjectbeta responseen_US
dc.titleIncreased Beta Frequency (15-30 Hz) Oscillatory Responses in Euthymic Bipolar Patients Under Lithium Monotherapyen_US
dc.typeArticle
dspace.entity.typePublication

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