Ultra-structural hair alterations of drug abusers: a scanning electron microscopic investigation

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dc.authorid0000-0002-7415-3152en_US
dc.contributor.authorTurkmenoglu, Fatma Pinar
dc.contributor.authorKasirga, Ugur Baran
dc.contributor.authorCelik, Hakan Hamdi
dc.date.accessioned2024-07-12T21:49:47Z
dc.date.available2024-07-12T21:49:47Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAs drug abuse carries a societal stigma, patients do not often report their history of drug abuse to the healthcare providers. However, drug abuse is highly co-morbid with a host of other health problems such as psychiatric disorders and skin diseases, and majority of individuals with drug use disorders seek treatment in the first place for other problems. Therefore, it is very important for physicians to be aware of clinical signs and symptoms of drug use. Recently diagnostic value of dermatologic tissue alterations associated with drug abuse has become a very particular interest because skin changes were reported to be the earliest noticeable consequence of drug abuse prompting earlier intervention and treatment. Although hair is an annex of skin, alterations on hair structure due to drug use have not been demonstrated. This study represents the first report on ultra-structural hair alterations of drug abusers. We have investigated ultra-structure of the hair samples obtained from 6 cocaine, 6 heroin, 7 cannabis and 4 lysergic acid diethylamide (LSD) abusers by scanning electron microscope (SEM). SEM analysis of hair samples gave us drug-specific discriminating alterations. We suggest that results of this study will make a noteworthy contribution to cutaneous alterations associated with drug abuse which are regarded as the earliest clinical manifestations, and this SEM approach is a very specific and effective tool in the detection of abuse of respective drugs, leading early treatment.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination Unit [04A101008]en_US
dc.description.sponsorshipThis work supported by Hacettepe University Scientific Research Projects Coordination Unit (Project No: 04A101008). The authors would like to thank Aytekin Temizer, Pharm. PhD, who was professor in Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University and former head of Turkish Doping Control Center, which is a Hacettepe University unit, for providing hair samples and H. Evren cubukcu, PhD, who is assistant professor in Department of Geological Engineering, Faculty of Engineering, Hacettepe University, for his great help during SEM studies.en_US
dc.identifier.endpage8811en_US
dc.identifier.issn1940-5901
dc.identifier.issue6en_US
dc.identifier.pmid26309532en_US
dc.identifier.scopus2-s2.0-84938359602en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage8803en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8084
dc.identifier.volume8en_US
dc.identifier.wosWOS:000359295600050en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-CENTURY PUBLISHING CORPen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01281
dc.subjectCocaineen_US
dc.subjectheroinen_US
dc.subjectcannabisen_US
dc.subjectlysergic acid diethylamideen_US
dc.subjectLSDen_US
dc.subjectdrug abuseen_US
dc.subjecthairen_US
dc.subjectanatomyen_US
dc.subjectscanning electron microscopeen_US
dc.titleUltra-structural hair alterations of drug abusers: a scanning electron microscopic investigationen_US
dc.typeArticle
dspace.entity.typePublication

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