Biological aging and autoimmunity

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dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorSitar, Mustafa Erinç
dc.contributor.editorRezaei, Nima
dc.date.accessioned2024-07-12T21:13:48Z
dc.date.available2024-07-12T21:13:48Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractAll of the functional negative changes that occur in the organism during their lifespan are called “aging.” This phenomenon is a problem as old as the human history. Academicians and authorities of the societies tried to solve the problem on behalf of humanity. Although a lot of information has been obtained about it, not all of its biological mechanisms have been explained. During this process, the changes that occur in the body can be considered holistically or separately. Our immune system, both as a single system and together with other systems like neuroendocrine system, is either directly affected by aging or directly affects aging. Many changes occur, such as elevation of clonal T-cell subsets, postpuberty thymus involution, decline of the ability to differentiate between self and nonself, alteration of the cytokine profile with a tendency to proinflammatory direction, and change in the expression of cell surface receptors. Changes that occur in human immune system, which is also called immunocenescence, are directly associated with the increased risk of autoimmune diseases and malignancies. The procedures that can be done to ensure healthy aging, prevent autoimmune diseases, and decrease the cancer risk and prolong longevity are hidden in these mechanisms.en_US
dc.identifier.citationSitar, M.E. (2022). Biological aging and autoimmunity. Rezaei, N. (Ed.). Translational Autoimmunity içinde (ss.193-203.) San Diego: Elsevier.en_US
dc.identifier.doi10.1016/B978-0-12-824390-9.00016-5
dc.identifier.endpage203en_US
dc.identifier.isbn9.78032E+12
dc.identifier.scopus2-s2.0-85129426231en_US
dc.identifier.startpage193en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/B9780128243909000165
dc.identifier.urihttps://doi.prg/10.1016/B978-0-12-824390-9.00016-5
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4565
dc.identifier.volume2en_US
dc.indekslendigikaynakScopus
dc.institutionauthorSitar, Mustafa Erinç
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofTranslational Autoimmunityen_US
dc.relation.publicationcategoryUluslararası Kitapta Bölümen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY05765
dc.subjectAdaptive Immunityen_US
dc.subjectAgingen_US
dc.subjectAutoimmune diseasesen_US
dc.subjectInflammagingen_US
dc.subjectImmunosenescenceen_US
dc.subjectInnate immunityen_US
dc.titleBiological aging and autoimmunityen_US
dc.typeBook Part
dspace.entity.typePublication

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