High Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemia

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dc.authorid0000-0002-4936-3705en_US
dc.contributor.authorSayan, Ozkan
dc.contributor.authorKilicaslan, Emrah
dc.contributor.authorCelik, Serkan
dc.contributor.authorTangi, Fatih
dc.contributor.authorErikci, Alev A.
dc.contributor.authorIpcioglu, Osman
dc.contributor.authorSanisoglu, Yavuz S.
dc.contributor.authorNalbant, Selim
dc.contributor.authorOktenli, Cagatay
dc.date.accessioned2024-07-12T21:47:30Z
dc.date.available2024-07-12T21:47:30Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIn the present study, we aimed to determine the frequency of inherited variants in the MEFV (Mediterranean FeVer), the gene responsible for familial Mediterranean fever (FMF), gene in patients with acute lymphocytic leukemia (ALL). The eight MEFV gene variants (M694I, M694V, M680I (G/C-A), V726A, R761H, E148Q and P369S) were detected in 36 patients with ALL and 65 healthy controls; none had own and/or family history compatible with FMF. We identified 11 heterozygous inherited variants in the MEFV gene in both ALL patients and controls. The mean overall frequency of inherited variants in the MEFV gene rate was higher in ALL patients than healthy controls (P = 0.040). It is interesting to note that M680I/0 is predominant variant in patients with ALL. In addition, E148Q variant frequency was also significantly higher in the patient group than the controls (P = 0.012). In conclusion, overall frequency of inherited variants in the MEFV gene was found to be higher in patients with ALL. Based on the present data, it is difficult to reach a definitive conclusion regarding the possibility that inherited variants in the MEFV gene could represent a causative role in ALL. However, the data of our study may provide some new insights in understanding of individual genetic differences in susceptibility to these neoplasms. Further investigations are needed to determine the actual role of inherited variants in the MEFV gene in pathogenesis of ALL.en_US
dc.identifier.doi10.1007/s12288-011-0095-x
dc.identifier.endpage168en_US
dc.identifier.issn0971-4502
dc.identifier.issue3en_US
dc.identifier.pmid22942567en_US
dc.identifier.scopus2-s2.0-80053906095en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12288-011-0095-x
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8049
dc.identifier.volume27en_US
dc.identifier.wosWOS:000293856200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGER INDIAen_US
dc.relation.ispartofINDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01231
dc.subjectMEFV geneen_US
dc.subjectAcute lymphocytic leukemiaen_US
dc.subjectInterleukin-1 betaen_US
dc.subjectNuclear factor-kappa Ben_US
dc.titleHigh Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemiaen_US
dc.typeArticle
dspace.entity.typePublication

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