Prognostic role of serum vascular endothelial growth factor, basic fibroblast growth factor and nitric oxide in patients with colorectal carcinoma

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dc.authorid0000-0001-6872-3780en_US
dc.contributor.authorAkbulut, H
dc.contributor.authorAltuntas, F
dc.contributor.authorAkbulut, KG
dc.contributor.authorOzturk, G
dc.contributor.authorCindoruk, M
dc.contributor.authorUnal, E
dc.contributor.authorIcli, F
dc.date.accessioned2024-07-12T21:46:06Z
dc.date.available2024-07-12T21:46:06Z
dc.date.issued2002en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractRecently, angiogenesis has gained an increasing interest as a prognostic factor in a variety of solid tumours. In this study we aimed to assess the prognostic role of serum vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF) and nitric oxide (NO) levels in patients with colorectal carcinoma (CRC). A total of 52 consecutive colorectal cancer patients with stage I to IV disease was included. In addition to routine laboratory and staging procedures, serum VEGF, b-FGF levels, and nitrate levels as a surrogate marker for in-vivo NO production were assayed. Serum VEGF concentrations, adjusted to the platelet count were found to be a significant factor for overall survival in univariate analysis (P = 0.033). A new angiogenic index (AI), derived from serum VEGF and nitrate concentrations, was established. AI is the only independent prognostic factor of survival in all patients (P = 0.008, Cox regression analysis). Likewise, AI is also significant prognostic factor for disease-free survival (DFS) in patients with operable CRC (P = 0.032, Cox regression analysis). In conclusion, serum VEGF and NO levels have prognostic role in patients with CRC and the new angiogenesis index using the serum levels of the factors seem to be useful. (C) 2002 Elsevier Science Ltd. All rights reserved.en_US
dc.identifier.doi10.1006/cyto.2002.1993
dc.identifier.endpage190en_US
dc.identifier.issn1043-4666
dc.identifier.issue4en_US
dc.identifier.pmid12543084en_US
dc.identifier.scopus2-s2.0-0043023494en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage184en_US
dc.identifier.urihttps://dx.doi.org/10.1006/cyto.2002.1993
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7891
dc.identifier.volume20en_US
dc.identifier.wosWOS:000180759000008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherACADEMIC PRESS LTD ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofCYTOKINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00600
dc.subjectVEGFen_US
dc.subjectb-FGFen_US
dc.subjectnitric oxideen_US
dc.subjectcolorectal carcinomaen_US
dc.titlePrognostic role of serum vascular endothelial growth factor, basic fibroblast growth factor and nitric oxide in patients with colorectal carcinomaen_US
dc.typeArticle
dspace.entity.typePublication

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