Cerebral blood flow changes in patients with probable medication-overuse headache

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dc.authorid0000-0003-2016-9965en_US
dc.contributor.authorSavrun F.K.
dc.contributor.authorGoksan B.
dc.contributor.authorSavrun M.
dc.contributor.authorSahin R.
dc.contributor.authorSahin S.
dc.date.accessioned2024-07-12T21:47:06Z
dc.date.available2024-07-12T21:47:06Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractTranscranial Doppler (TCD) is a non-invasive method for measuring blood flow velocity (BFV), and a marker of vessel diameter. In this study, intracranial BFV was investigated, by means of TCD, in patients suffering from probable medication-overuse headache (PMOH). Twenty-three female patients with probable ergotamine-overuse headache (PEOH), 23 female patients with probable analgesic-overuse headache (PAOH), and 15 healthy female controls participated in the study. The mean BFVs of the bilateral middle and anterior cerebral arteries (MCA and ACA) and basilar artery (BA) were measured by TCD. The mean BFVs of the BA and MCA were found to be significantly increased in the PEOH group when compared with those of the PAOH and control groups (p<0.05). No significant differences in BFV of the ACA were observed between any groups (p>0.05). The mean BFV of all the vessels in the PAOH group was found to be lower than that of the control group but no statistical significance was found (p>0.05). Our results show that ergotamine increases BFV via vasoconstriction, especially of the BA and MCA. We also suggest that 5HT1B/1D receptors are mainly localized in the BA and MCA, and that analgesic overuse results in a functional disorder of neuronal receptor and neurovascular reflexes and may cause a reduction of intracerebral vessel tone, leading to vasodilatation.en_US
dc.identifier.endpage86en_US
dc.identifier.issn0393-5264
dc.identifier.issue2en_US
dc.identifier.pmid18671908en_US
dc.identifier.scopus2-s2.0-50849145219en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8005
dc.identifier.volume23en_US
dc.identifier.wosWOS:000259811000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofFunctional Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01060
dc.subjectAnalgesicen_US
dc.subjectCerebral blood flowen_US
dc.subjectErgotamineen_US
dc.subjectHeadacheen_US
dc.subjectOveruseen_US
dc.subjectTranscranial Doppleren_US
dc.titleCerebral blood flow changes in patients with probable medication-overuse headacheen_US
dc.typeArticle
dspace.entity.typePublication

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