Epigenetic alterations of preimplantation embryo
dc.authorid | 0000-0002-0717-1756 | en_US |
dc.authorid | 0000-0003-3771-3277 | en_US |
dc.contributor.author | Cıncık, Mehmet | |
dc.contributor.author | Öner, Çağrı | |
dc.contributor.editor | Bilgili, Ali | |
dc.date.accessioned | 2024-07-12T21:13:58Z | |
dc.date.available | 2024-07-12T21:13:58Z | |
dc.date.issued | 2022 | en_US |
dc.department | Fakülteler, Tıp Fakültesi | en_US |
dc.description.abstract | Epigenetics refers to phenomena where modifications of DNA methylation and/or chromatin structure underlie changes in gene expression and phenotype characteristics (Reik et al., 2001; Soini et al., 2006). These modifications include DNA methylation, imprinting, RNA silencing, covalent modifications of histones (acetylation), and remodeling by other chromatin-associated complexes (Dupont et al., 2009). Inheritance or persistence of these epigenetic modifications is referred to as epigenetic reprogramming (Morgan et al., 2005). The most critical periods at which epigenetic reprogramming occurs are those during gametogenesis and the preimplantation embryonic stage (Reik et al., 2001; Santos and Dean, 2004). Reprogramming during gametogenesis is essential for the imprinting mechanism that regulates the differential expression of paternally and maternally derived genes. Primordial germ cells undergo demethylation, both globally (Hajkova, P. et al., 2002) and within imprinted loci as they migrate along the genital ridge (Hajkova, P. et al., 2002; Yamazaki et al., 2003). These alterations to the DNA allow cells to alter the expression level of the different genes in response to environmental factors without having to change the DNA code itself (Jacob, S. and Moley, K. H., 2005). Various techniques in ART have been developed, some of which are quite invasive: intracytoplasmic sperm injection (ICSI) with mature and immature spermatozoa, embryo biopsy for preimplantation genetic diagnosis (PGD) and transfer of ooplasm to a recipient oocyte. Finally, reproductive cloning by nuclear transfer, MII spindle transfer has been achieved in different animal species (Reznichenko et al., 2016). Recently, several confluent streams of evidence from human and animal studies have suggested that ART may lead to epigenetic defects in the offspring (Jacob, S. and Moley, K. H., 2005; Maher, 2005; Niemitz, E. L. and Feinberg, A. P., 2004; PaoloniGiacobino, 2006; Sutcliffe et al., 2006; Thompson and Williams, 2005; Yoon et al., 2005). | en_US |
dc.identifier.citation | Cıncık, M. ve Öner, Ç. (2022). Epigenetic alterations of preimplantation embryo. Bilgili, A. (Ed.). INSAC Contemporary Trends in Human and Health Sciences Research içinde (ss.69-99). Ankara: Duvar Kitabevi. | en_US |
dc.identifier.endpage | 99 | en_US |
dc.identifier.isbn | 978-625-8109-00-9 | |
dc.identifier.startpage | 69 | en_US |
dc.identifier.uri | https://www.insackongre.com/book | |
dc.identifier.uri | https://hdl.handle.net/20.500.12415/4579 | |
dc.institutionauthor | Cıncık, Mehmet | |
dc.institutionauthor | Öner, Çağrı | |
dc.language.iso | en | en_US |
dc.publisher | Duvar Kitabevi | en_US |
dc.relation.ispartof | INSAC Contemporary Trends in Human and Health Sciences Research | en_US |
dc.relation.publicationcategory | Uluslararası Konferans Öğesi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.snmz | KY07463 | |
dc.title | Epigenetic alterations of preimplantation embryo | en_US |
dc.type | Conference Object | |
dspace.entity.type | Publication |