Effect of melatonin treatment on liver and thymus zinc levels in young and middle-aged rats

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dc.contributor.authorOzturk, G
dc.contributor.authorAkbulut, KG
dc.contributor.authorAfrasyap, L
dc.contributor.authorSevinc, D
dc.date.accessioned2024-07-12T21:51:36Z
dc.date.available2024-07-12T21:51:36Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractMelatonin (MEL) is the main neurohormone of the pineal gland. Zinc (Zn) is an essential trace element that is required as a catalytic component for more than 200 enzymes. Both MEL and Zn are considered beneficial for anti-immunosenescence. Recent Findings have shown that MEL can modulate Zn turnover. The aim of this study was to investigate the effect of MEL treatment on the tissue Zn levels in young (4 months) and middle-aged (14 months) rats. Male wistar rats received during 3 weeks subcutaneous injection of MEL (10 mg/kg). After 3 weeks, rats were decapitated and tissue samples were collected. Zn levels were measured by spectrophotometric assay. In conclusion, MEL decreased liver Zn levels both in young and middle-aged rats. In addition, Zn levels in young control group were significantly higher than middle-aged control group. However, MEL treatment increased thymus Zn levels in middle-aged group compared with the control. These findings indicate that tissue Zn levels are significantly affected by MEL treatment.en_US
dc.identifier.doi10.1002/jtra.10055
dc.identifier.endpage80en_US
dc.identifier.issn0896-548X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-1642499568en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jtra.10055
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8288
dc.identifier.volume17en_US
dc.identifier.wosWOS:000188546700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherWILEY-LISSen_US
dc.relation.ispartofJOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY02083
dc.subjectmelatoninen_US
dc.subjectzincen_US
dc.subjectliveren_US
dc.subjectthymusen_US
dc.titleEffect of melatonin treatment on liver and thymus zinc levels in young and middle-aged ratsen_US
dc.typeArticle
dspace.entity.typePublication

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