Comparison of Sexual Function and Hormonal Parameters Between Mood Stabilizer Treatment Modalities in Bipolar Disorder

Basit Öğe Kaydı
dc.contributor.authorKesebir, Sermin
dc.contributor.authorToprak, Burak
dc.contributor.authorBaykaran, Burak
dc.contributor.authorHariri, Aytul
dc.contributor.authorBilici, Mustafa
dc.date.accessioned2024-07-12T21:52:34Z
dc.date.available2024-07-12T21:52:34Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIntroduction: The aim of this study was to determine the differences between lithium and atypical antipsychotics (quetiapine and olanzapine) with regard to their effects on sexual functions and hormonal variables and to assess the findings in term of gender differences, in patients with bipolar disorder. Method: 28 female and 29 male patients diagnosed as having bipolar disorder type I according to the DSM-IV, using lithium or quetiapine and quetiapine+lithium or olanzapine and olanzapine+lithium were evaluated consecutively. Being in remission period and given informed consent were set as inclusion criteria in these cases. Interviews with the patients were carried out using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and SKIP-TURK. Sexual functions and satisfaction were evaluated with the Arizona Sexual Experiences Scale (ASEX) and the Golombok Rust Inventory of Sexual Satisfaction (GRISS). Blood samples of the patients were taken in order to determine prolactin (PRL), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and free testosterone (T) levels. Results: GRISS scores in male patients were higher than in female patients (p=0.001). The number of manic, depressive and total episodes, and functionality levels were similar between the treatment groups, both in female and male patients. No differences were found between treatment modalities in terms of hormone levels both in female and male patients. Among females, ASEX scores of the patients treated with lithium monotherapy were less than the ones treated with quetiapine and olanzapine. Among patients with quetiapine monotherapy, GRISS scores in male patients were higher than in female patients. Conclusion: There are some evidences showing gender-based differences in the side effects of atypical antipsychotic drugs. Future studies with a specific focus on this topic are needed in order to have a better understanding of the basic mechanisms of gender differences.en_US
dc.identifier.doi10.4274/npa.y6838
dc.identifier.endpage247en_US
dc.identifier.issn1300-0667
dc.identifier.issue3en_US
dc.identifier.pmid28360633en_US
dc.identifier.scopus2-s2.0-84907849181en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage242en_US
dc.identifier.urihttps://dx.doi.org/10.4274/npa.y6838
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8403
dc.identifier.volume51en_US
dc.identifier.wosWOS:000346118900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.publisherGALENOS YAYINCILIKen_US
dc.relation.ispartofNOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03143
dc.subjectGenderen_US
dc.subjectsexual side effecten_US
dc.subjectpsychotropicsen_US
dc.subjectbipolar disorderen_US
dc.titleComparison of Sexual Function and Hormonal Parameters Between Mood Stabilizer Treatment Modalities in Bipolar Disorderen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu