Pentoxifylline Inhibits Epidural Fibrosis in Post-Laminectomy Rats

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dc.authorid0000-0002-8313-4092en_US
dc.authorid0000-0002-5300-4449en_US
dc.authorid0000-0002-4713-4271en_US
dc.contributor.authorKelten, Bilal
dc.contributor.authorErdogan, Hakan
dc.contributor.authorAntar, Veysel
dc.contributor.authorSanel, Selim
dc.contributor.authorTuncdemir, Matem
dc.contributor.authorKutnu, Muge
dc.contributor.authorKaraoglan, Alper
dc.contributor.authorOrki, Tulay
dc.date.accessioned2024-07-12T21:51:58Z
dc.date.available2024-07-12T21:51:58Z
dc.date.issued2016en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: The aim of this experimental study was to investigate the effectiveness of intramuscular pentoxifylline in the prevention of postoperative fibrosis. Material/Methods: We divided 16 adult Wistar albino rats into 2 equal groups: treatment and control. Both groups underwent L1 vertebral total laminectomy to expose the dura. The intramuscular treatment group received pentoxifylline. Four weeks later, epidural fibrosis was studied in both groups using electron microscopy, light microscopy, histology, biochemistry, and macroscopy. Results: The evaluation of epidural fibrosis in the 2 groups according to macroscopic (p<0.01) assessment and light microscopy revealed that epidural scar tissue formation was lower in the treatment group compared to the control group (p<0.001) and the number of fibroblasts was also decreased significantly in the pentoxifylline-treated group (p<0.05). More immature fibers were demonstrated in the treatment group by electron microscopy in comparison with the control group. In biochemical analysis, a statistically significant decrease was detected in hydroxyproline, which indicates fibrosis and myeloperoxidase activity, and shows an inflammatory response (P<0.001). Conclusions: Systemic pentoxifylline application prevents postoperative epidural fibrosis and adhesions with various mechanisms. Our study is the first to present evidence of experimental epidural fibrosis prevention with pentoxifylline.en_US
dc.identifier.doi10.12659/MSM.897668
dc.identifier.endpage847en_US
dc.identifier.issn1643-3750
dc.identifier.pmid26974057en_US
dc.identifier.scopus2-s2.0-84961262865en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage840en_US
dc.identifier.urihttps://dx.doi.org/10.12659/MSM.897668
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8336
dc.identifier.volume22en_US
dc.identifier.wosWOS:000372064500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherINT SCIENTIFIC LITERATURE, INCen_US
dc.relation.ispartofMEDICAL SCIENCE MONITORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY02887
dc.subjectAnimal Experimentationen_US
dc.subjectLaminectomyen_US
dc.subjectPentoxifyllineen_US
dc.titlePentoxifylline Inhibits Epidural Fibrosis in Post-Laminectomy Ratsen_US
dc.typeArticle
dspace.entity.typePublication

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