Western Diet and Cognitive Impairment: Links to Potential Mechanisms: A Review

Küçük Resim Yok

Tarih

2023

Yazarlar

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Shiraz University of Medical Sciences

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Araştırma projeleri

Organizasyon Birimleri

Dergi sayısı

Özet

Animal studies in recent years have shown that a Western diet style (WD-style) which is high in saturated fat and refined carbohydrates causes obesity, metabolic syndrome and cardiovascular diseases. In addition, results demonstrated that it can damage the structures that make up the nervous system. Accordingly, there is an evidence that systemic changes associated with the Western diet lead to blood-brain barrier (BBB) disruption, microglia activation, and the development of neuroinflammation. These changes are then followed by synaptic transmission dysfunction, neurodegeneration, and finally memory and cognitive deterioration. This review summarizes research on the mechanisms that show Western diet consumption is associated with cognitive impairment, with emphasis on learning and memory functions that depend on the integrity of the hippocampus. © 2023, Shiraz University of Medical Sciences. All rights reserved.

Açıklama

Anahtar Kelimeler

Cognitive Functions, Learning, Memory, Neuroinflammation, Western Diet

Kaynak

International Journal of Nutrition Sciences

WoS Q Değeri

Scopus Q Değeri

N/A

Cilt

8

Sayı

3

Künye