Comparison of Effects of Separate and Combined Sugammadex and Lipid Emulsion Administration on Hemodynamic Parameters and Survival in a Rat Model of Verapamil Toxicity

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dc.authorid0000-0003-1996-7505en_US
dc.contributor.authorTulgar, Serkan
dc.contributor.authorKose, Halil Cihan
dc.contributor.authorPiroglu, Isilay Demir
dc.contributor.authorKarakilic, Evvah
dc.contributor.authorAtes, Nagihan Gozde
dc.contributor.authorDemir, Ahmet
dc.contributor.authorGergerli, Ruken
dc.contributor.authorGuven, Selin
dc.contributor.authorPiroglu, Mustafa Devrim
dc.date.accessioned2024-07-12T21:51:59Z
dc.date.available2024-07-12T21:51:59Z
dc.date.issued2016en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Toxicity of calcium channel blockers leads to high patient mortality and there is no effective antidote. The benefit of using 20% lipid emulsion and sugammadex has been reported. The present study measured the effect of sugammadex and 20% lipid emulsion on hemodynamics and survival in a rat model of verapamil toxicity. Material/Methods: In this single-blinded randomized control study, rats were separated into 4 groups of 7 rats each: Sugammadex (S), Sugammadex plus 20% lipid emulsion (SL), 20% lipid emulsion (L), and control (C). Heart rates and mean arterial pressures were monitored and noted each minute until death. Results: Average time to death was 21.0 +/- 9.57 minutes for group C, 35.57 +/- 10.61 minutes for group S, 37.14 +/- 16.6 minutes for group L and 49.86 +/- 27.56 minutes for group SL. Time to death was significantly longer in other groups than in the control group (p<0.05). Conclusions: Verapamil overdose is has a comparatively high mortality rate and there is no effective antidote. Treatment generally involves gastric decontamination and symptomatic treatment to counteract the drug's negative effects. In animal studies sugammadex and lipid emulsion had a positive effect on survival in patients with calcium channel blocker toxicity. Sugammadex and intralipid increased survival in a rat model of verapamil toxicity. The combination of both drugs may decrease cardiotoxicity. Sugammadex alone or combined with 20% lipid emulsion reduce the need for inotropic agents. The mechanism requires clarification with larger studies.en_US
dc.identifier.doi10.12659/MSM.896125
dc.identifier.endpage990en_US
dc.identifier.issn1643-3750
dc.identifier.pmid27012816en_US
dc.identifier.scopus2-s2.0-84961720266en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage984en_US
dc.identifier.urihttps://dx.doi.org/10.12659/MSM.896125
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8337
dc.identifier.volume22en_US
dc.identifier.wosWOS:000372837700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherINT SCIENTIFIC LITERATURE, INCen_US
dc.relation.ispartofMEDICAL SCIENCE MONITORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY02888
dc.subjectDrug Overdoseen_US
dc.subjectFat Emulsions, Intravenousen_US
dc.subjectgamma-Cyclodextrinsen_US
dc.subjectVerapamilen_US
dc.titleComparison of Effects of Separate and Combined Sugammadex and Lipid Emulsion Administration on Hemodynamic Parameters and Survival in a Rat Model of Verapamil Toxicityen_US
dc.typeArticle
dspace.entity.typePublication

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