Plasma growth arrest-specific 6 levels in term and preterm newborns

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dc.contributor.authorAlp, Emel Eksi
dc.contributor.authorAltinkaya, Nuvit
dc.contributor.authorCagman, Zeynep
dc.contributor.authorUras, Fikriye
dc.date.accessioned2024-07-12T21:50:53Z
dc.date.available2024-07-12T21:50:53Z
dc.date.issued2018en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: Growth Arrest-Specific 6 (GAS6) is a vitamin K-dependent protein. Despite a similar structure to Protein S, it has no anticoagulant activity. An association between GAS6 and some diseases for adults has been reported. In the absence of prospective clinical studies of GAS6 in neonates, so far, the objective of this study is to obtain, for the first time, plasma GAS6 levels before and after vitamin K1 prophylaxis in full-term and pre-term newborns.Methods: 80 newborns (40 term and 40 preterm) were recruited for this study. Cord blood samples and peripheral blood samples 48h after vitamin K1 injection were collected into EDTA-tubes. GAS6 levels were measured in platelet-poor plasma by ELISA.Results: Cord blood plasma GAS6 levels in preterm and term newborns were 9.075.30ng/mL and 9.75 +/- 4.34ng/mL, respectively. In response to vitamin K1 injection, GAS6 levels increased in preterm newborns (10.50 +/- 5.28ng/mL) (p<.05), but not in term newborns (9.12 +/- 3.42ng/mL, p>.05).Conclusion: This pilot study provided, to the best of our knowledge, the first report that GAS6 levels increased significantly after vitamin K1 prophylaxis in preterm newborns but not in term infants. This study may serve as a first step toward more extensive studies in neonates.en_US
dc.identifier.doi10.1080/14767058.2017.1311311
dc.identifier.endpage1155en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue9en_US
dc.identifier.pmid28335649en_US
dc.identifier.scopus2-s2.0-85017410277en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1151en_US
dc.identifier.urihttps://dx.doi.org/10.1080/14767058.2017.1311311
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8218
dc.identifier.volume31en_US
dc.identifier.wosWOS:000427919300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01960
dc.subjectGAS6en_US
dc.subjectvitamin Ken_US
dc.subjectnewbornen_US
dc.subjecttermen_US
dc.subjectpretermen_US
dc.subjectfetal growth retardationen_US
dc.titlePlasma growth arrest-specific 6 levels in term and preterm newbornsen_US
dc.typeArticle
dspace.entity.typePublication

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