Does Hyperbaric Oxygen Administration Before or After Irradiation Decrease Side Effects of Irradiation on Implant Sites?

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dc.authorid0000-0003-0469-2801en_US
dc.contributor.authorTumerdem-Ulug, Burcak
dc.contributor.authorKuran, Ismail
dc.contributor.authorOzden, Burcu C.
dc.contributor.authorMete, Ozgur
dc.contributor.authorKemikler, Gonul
dc.contributor.authorAktas, Samil
dc.contributor.authorCalik, Burcu
dc.date.accessioned2024-07-12T21:45:01Z
dc.date.available2024-07-12T21:45:01Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: One of the main limitations of implant-based breast reconstruction is the high rate of complications such as capsular contracture and poor aesthetic outcome, due to adjuvant radiotherapy. Hyperbaric oxygen treatment (HBOT) has been used to assist wound healing in the prevention and treatment of the side effects of irradiation. We aimed to investigate this effect of HBOT on the capsule reaction and skin, applied before and after irradiation, following the placement of an implant under the dorsal skin of the rat. Methods: Fifteen Wistar rats were randomly divided into 3 groups. A 18-mL smooth testicular implant was introduced into a subcutaneous pocket located on the dorsum of each rat. A single dose of 17-Gy irradiation was given to the implanted area of each rat at the third week. HBOT which lasted 3 weeks was administered to group I before irradiation, group II after irradiation. The control group did not receive HBOT. All of the rats were killed at the ninth week (6 weeks after irradiation). The dorsal skin with the capsule overlying the implant were excised for histopathological processing. The thickness of the capsule reaction of each group was evaluated statistically. Results: Our histopathological examination revealed changes due to radiation in the control group. Many of these findings were found to be more subtle in group I and nearly absent in the group II. There was not any statistical difference between the thickness of the capsule reactions of the control group and group I, or group I and group II, but the capsular thickness of the control group was statistically higher than group II. Conclusion: It can be predicted that the use of HBOT following irradiation is an effective tool to reduce the capsule reaction of the implanted area and the tissue damage seen in radiodermatitis.en_US
dc.identifier.doi10.1097/SAP.0b013e3181e6cfa4
dc.identifier.endpage67en_US
dc.identifier.issn0148-7043
dc.identifier.issue1en_US
dc.identifier.pmid21301311en_US
dc.identifier.scopus2-s2.0-79959756706en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://dx.doi.org/10.1097/SAP.0b013e3181e6cfa4
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7775
dc.identifier.volume67en_US
dc.identifier.wosWOS:000291587200015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofANNALS OF PLASTIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00270
dc.subjecthyperbaric oxygen treatmenten_US
dc.subjectirradiationen_US
dc.subjectimplanten_US
dc.subjectcapsuleen_US
dc.titleDoes Hyperbaric Oxygen Administration Before or After Irradiation Decrease Side Effects of Irradiation on Implant Sites?en_US
dc.typeArticle
dspace.entity.typePublication

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