Enhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled release

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dc.authoridYılmaz, Mahmut/0000-0001-5793-0805en_US
dc.authoridTuna, Bilge Güvenc/0000-0003-1348-1336en_US
dc.authoridÖzalp, Veli Cengiz/0000-0002-7659-5990en_US
dc.authoridThomas, Pınar Buket/0000-0001-7627-0291en_US
dc.authoridYesilay, Gamze/0000-0002-3375-8956en_US
dc.authoridKara, Kübra/0000-0002-6639-0924en_US
dc.contributor.authorTuna, Bilge G.
dc.contributor.authorAtalay, Pınar B.
dc.contributor.authorKuku, Gamze
dc.contributor.authorAcar, E. Esma
dc.contributor.authorKara, H. Kübra
dc.contributor.authorYılmaz, M. Deniz
dc.contributor.authorÖzalp, V. Cengiz
dc.date.accessioned2024-07-12T21:37:59Z
dc.date.available2024-07-12T21:37:59Z
dc.date.issued2019en_US
dc.department[Belirlenecek]en_US
dc.description.abstractCarbendazim, is a broad-spectrum fungicide and also a promising experimental antitumor drug as reproduction and developmental toxicant, which is currently under phase II preclinical trials. In this study, an approach based on controlled and targeted release with aptamers and mesoporous silica nanoparticles was investigated to improve the antitumor activity of carbendazim. To this end, we synthesized aptamer conjugated silica nanoparticles for testing cytotoxicity properties in vitro with human cervical adenocarcinoma (HeLa) cultured cells. Nucleolin (AS1411) binding aptamers were used to entrap carbendazim molecules inside nanopores of MCM-41 type silica nanoparticles to obtain a stimuli-dependent release system. The effect of carbendazim loaded aptamer silica complex was tested and compared to free carbendazim treatment on HeLa cells, demonstrating 3.3 fold increase of toxicity on targeted cells with our delivery system. In addition, cytotoxicity of the complex was determined to be mostly due to increased apoptosis and to a less extend necrosis related pathways.en_US
dc.identifier.doi10.1039/c9ra07974b
dc.identifier.endpage36010en_US
dc.identifier.issn2046-2069
dc.identifier.issue62en_US
dc.identifier.pmid35540590en_US
dc.identifier.scopus2-s2.0-85075003926en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage36005en_US
dc.identifier.urihttps://doi.org/10.1039/c9ra07974b
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7012
dc.identifier.volume9en_US
dc.identifier.wosWOS:000497825500010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04354
dc.titleEnhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled releaseen_US
dc.typeArticle
dspace.entity.typePublication

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