Patients with Mild Cognitive Impairment Display Reduced Auditory Event-Related Delta Oscillatory Responses

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dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0001-7042-697Xen_US
dc.contributor.authorKurt, Pinar
dc.contributor.authorEmek-Savas, Derya Durusu
dc.contributor.authorBatum, Kubra
dc.contributor.authorTurp, Bilge
dc.contributor.authorGuntekin, Bahar
dc.contributor.authorKarsidag, Sibel
dc.contributor.authorYener, Gorsev Gulmen
dc.date.accessioned2024-07-12T21:45:12Z
dc.date.available2024-07-12T21:45:12Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground. Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory eventrelated delta oscillations of MCI subjects. Method. The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age-and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded from F-3, F-z, F-4, C-3, C-z, C-4, P-3, P-z, P-4, O-1, O-z, and O-2 locations. The maximum peak-to-peak amplitudes for each subject's averaged delta response (0.5-2.2Hz) weremeasured. Results. The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect for groups (F-(1.41) = 4.84, P = 0.033), indicating a larger delta response for healthy controls thanMCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites F-3, F-z, F-4, C-z, C-4, and Pz. Discussion. Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [112S459]en_US
dc.description.sponsorshipThis study has been founded by the Scientific and Technological Research Council of Turkey (Project no. 112S459).en_US
dc.identifier.doi10.1155/2014/268967
dc.identifier.issn0953-4180
dc.identifier.issn1875-8584
dc.identifier.pmid24825953en_US
dc.identifier.scopus2-s2.0-84898619064en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2014/268967
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7810
dc.identifier.wosWOS:000333848200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHINDAWI PUBLISHING CORPORATIONen_US
dc.relation.ispartofBEHAVIOURAL NEUROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00408
dc.titlePatients with Mild Cognitive Impairment Display Reduced Auditory Event-Related Delta Oscillatory Responsesen_US
dc.typeArticle
dspace.entity.typePublication

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