Do deferoxamine, ticlopidine or trimetazidine prevent sevoflurane nephrotoxicity? An electron microscopic study
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cambridge University Press
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Sevoflurane is a common anesthetic drug. Several biochemical, pharmacologic and physiologic studies have showed nephrotoxicity of Sevoflurane[1,2,3]. Histopathologic studies reported tubular damage and tubular cellular hyperplasia after the administration of Sevoflurane[4]. Deferoxamine(DFO) is known to protect against myoglobinuric acute renal failure[5]. It has been suggested that Ticlopidine(TIC) does not prevent nephropathies but has beneficial effects[6]. Fang et al. showed that TIC inhibited mesangial cell proliferation and collagen synthesis[7]. There is another study reporting that TIC induces acute interstitial nephrite and cause an increase of the number of lymphocytes and eosinophil leucocytes in interstitial tissue[8]. Trimetazidine(TMZ) has anti-ischemic effects and protects tissue damage in kidney[5, 9, 10, 11]. These studies lead us to investigate if DFO, TIC or TMZ can prevent the nephrotoxicity of Sevoflurane at morphologic level.
Açıklama
Anahtar Kelimeler
Kaynak
Microscopy and Microanalysis
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
9
Sayı
2
Künye
Karamanlıoğlu, B. ve Aktaş, R. G. (2003). Do deferoxamine, ticlopidine or trimetazidine prevent sevoflurane nephrotoxicity? An electron microscopic study. Microscopy and Microanalysis, Cambridge University Press. 9(2), s. 1428-1429.
