Reperfusion strategy after regional ischaemia: Comparative study of reperfusion conditions and compositions

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dc.contributor.authorOguş N.T.
dc.contributor.authorUs M.H.
dc.contributor.authorOguş H.
dc.contributor.authorÖztürk Ö.Y.
dc.contributor.authorIşik Ö.
dc.date.accessioned2024-07-12T21:50:49Z
dc.date.available2024-07-12T21:50:49Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractWe investigated the effects of pressure, temperature and additives on aortic root reperfusion success. Cardiopulmonary bypass and heart arrest were initiated in mongrel dogs and sudden uncontrolled normothermic (group 1), pressure controlled substrate enriched normothermic (group 2a), pressure controlled unmodified normothermic (group 2b) and pressure controlled unmodified tepid (group 3) reperfusion compared. In group 1, the first cardiac rhythm was ventricular fibrillation, but dogs in the other groups showed spontaneous sinus rhythm. Recovery times were signigicantly decreased in group 1 compared with other groups. Prolonged lactate production and oxygen uptake failure were observed in group 1 compared with the other groups; oxidate stress markers and microscopic studies confirmed significant tissue injury in group 1. All parameters were similar between groups 2a, 2b and 3, indicating that low reperfusion pressure in the first 2 min is the most effective component of reperfusion. Copyright © 2004 Cambridge Medical Publications.en_US
dc.identifier.doi10.1177/147323000403200309
dc.identifier.endpage303en_US
dc.identifier.issn0300-0605
dc.identifier.issue3en_US
dc.identifier.pmid15174223en_US
dc.identifier.scopus2-s2.0-2442697907en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage292en_US
dc.identifier.urihttps://dx.doi.org/10.1177/147323000403200309
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8208
dc.identifier.volume32en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCambridge Medical Publicationsen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01932
dc.subjectControlen_US
dc.subjectGlutamateen_US
dc.subjectInjuryen_US
dc.subjectReperfusionen_US
dc.subjectTepiden_US
dc.subjectWarmen_US
dc.titleReperfusion strategy after regional ischaemia: Comparative study of reperfusion conditions and compositionsen_US
dc.typeArticle
dspace.entity.typePublication

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