Effects of spirulina on cyclophosphamide-induced ovarian toxicity in rats: Biochemical and histomorphometric evaluation of the ovary

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dc.authorid0000-0002-9252-4818en_US
dc.authorid0000-0002-4627-8628en_US
dc.authorid0000-0001-8682-5027en_US
dc.authorid0000-0002-0774-2766en_US
dc.authorid0000-0003-4449-1190en_US
dc.contributor.authorYener N.A.
dc.contributor.authorSinanoglu O.
dc.contributor.authorIlter E.
dc.contributor.authorCelik A.
dc.contributor.authorSezgin G.
dc.contributor.authorMidi A.
dc.contributor.authorDeveci, Uğur
dc.contributor.authorAksungar F.
dc.contributor.authorDeveci, Uğur
dc.date.accessioned2024-07-12T21:44:08Z
dc.date.available2024-07-12T21:44:08Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractCyclophosphamide (Cyc) is known to cause ovotoxicity and infertility in women. Our aim is to investigate the possible ovotoxic effects of Cyc and possible antioxidant and protective effects of blue-green algae, Spirulina (Sp), in rat ovaries. Eighteen rats were given: group I (n = 6, control); group II (n = 6, CP), a single dose Cyc; group III (n = 6, Sp+Cyc), 7 days Sp+single dose Cyc. Tissue malondialdehyde (MDA) levels, superoxide dismutase (SOD), and catalase (CAT) activities are assessed biochemically. Normal and atretic primordial and primary follicle counts for all sections obtained for each ovary are calculated. Mean number of follicle counts for each group are compared. In Sp+Cyc group, tissue MDA levels were significantly lower than those in the CP and higher than those in the C group (CP > Sp + Cyc > C). Tissue SOD activity was significantly higher in Sp+Cyc group than that in the CP group and lower than that in the C group (C > Sp + Cyc > C). No statistically significant difference was found between the ovarian CAT activities in any group. Histomorphometrically, there was also no significant difference between the mean numbers of normal and atretic small follicle counts. Our results suggest that single dose Cyc has adverse effects on oxidant status of the ovaries and Sp has protective effects in Cyc-induced ovotoxicity. © 2013 Nese Arzu Yener et al.en_US
dc.identifier.doi10.1155/2013/764262
dc.identifier.issn2090-2247
dc.identifier.pmid23762559en_US
dc.identifier.scopus2-s2.0-84878660131en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2013/764262
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7670
dc.identifier.wosWOS:000214690100021en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofBiochemistry Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00422
dc.titleEffects of spirulina on cyclophosphamide-induced ovarian toxicity in rats: Biochemical and histomorphometric evaluation of the ovaryen_US
dc.typeArticle
dspace.entity.typePublication

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