The effect of alpha-lipoic acid on NOS dispersion in the lung of streptozotocin-induced diabetic rats

Basit Öğe Kaydı
dc.authorid0000-0001-8219-4205en_US
dc.contributor.authorHurdag, Canan
dc.contributor.authorUyaner, Ilhan
dc.contributor.authorGurel, Ebru
dc.contributor.authorUtkusavas, Ayfer
dc.contributor.authorAtukeren, Pinar
dc.contributor.authorDemirci, Cilian
dc.date.accessioned2024-07-12T21:50:42Z
dc.date.available2024-07-12T21:50:42Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractOxidative stress and impaired bioactivity of nitric oxide (NO) play an important role in the organ pathogenesis and angiopathic complications of diabetes mellitus. In this study, we evaluated the effects of a-lipoic acid (ALA) on nitric oxide synthase (NOS) in lung tissues. ALA is a strong antioxidant. We wonder how it can affect oxidative stress and NO in the lung cells and vessels of diabetic rats. Wistar rats were divided into four groups; control, diabetic [65 mg/kg streptozotocin (STZ) for 15 days], STZ+ALA-treated (65 mg/kg ALA every 2 days for 15 days), and ALA-only-treated animals. At the end of the experimental period, lipid peroxidation, superoxide dismutase (SOD), and inducible NOS (iNOS) and endothelial NOS (eNOS) distribution were evaluated. Oxidative stress decreased with ALA in diabetic animals, and SOD also increased with ALA. iNOS and eNOS increased in diabetic animals, and ALA prevented iNOS increment in lung tissues. As a result, ALA can prevent some diabetic effects on the lungs and can also protect from vascular damages. (c) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jdiacomp.2006.08.004
dc.identifier.endpage61en_US
dc.identifier.issn1056-8727
dc.identifier.issue1en_US
dc.identifier.pmid18191078en_US
dc.identifier.scopus2-s2.0-37749030684en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage56en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jdiacomp.2006.08.004
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8189
dc.identifier.volume22en_US
dc.identifier.wosWOS:000252525800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofJOURNAL OF DIABETES AND ITS COMPLICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01887
dc.subjectalpha-lipoic aciden_US
dc.subjectNOSen_US
dc.subjectstreptozotocinen_US
dc.subjectlungen_US
dc.titleThe effect of alpha-lipoic acid on NOS dispersion in the lung of streptozotocin-induced diabetic ratsen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu