Low frequency of HLA-B27 in ankylosing spondylitis patients from Turkey

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dc.contributor.authorGunal, Esen Kasapoglu
dc.contributor.authorSarvan, Fatma Oguz
dc.contributor.authorKarnali, Sevil
dc.contributor.authorGul, Ahmet
dc.contributor.authorInanc, Murat
dc.contributor.authorCarin, Mahmut
dc.contributor.authorKonice, Meral
dc.contributor.authorAral, Orhan
dc.contributor.authorOcal, Lale
dc.date.accessioned2024-07-12T21:50:06Z
dc.date.available2024-07-12T21:50:06Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjectives: Ankylosing spondylitis is strongly associated with HLA-B27. However, the strength of the association with HLA-B27 and the clinical features may vary in different parts of the world. The aim of this study is to compare the clinical features of AS and the frequencies of HLA-B27 and its alleles in patients from Turkey with other series. Methods: One hundred and twelve patients (72 male/40 female) fulfilling the modified New York criteria for the classification of AS and 55 (27 male/28 female) healthy controls were typed for HLA-B27 and allele frequencies by sequence specific primer (PCR/SSP) method and assessed for clinical manifestations. Results: Male to female ratio was 1.8, mean age at disease onset was 23.5 and 24.1% of patients reported juvenile onset of symptoms. Peripheral arthritis was seen in 52.7% of patients. Family history (p = 0.01) and peripheral arthritis (p = 0.02) were more frequent in females and spinal involvement in males. HLA-B27 was found to be positive in 70% of patients and associated with younger mean age, uveitis and shorter time elapsed from symptom to diagnosis. The frequency of HLA-B27 alleles associated with SpA was not different between ankylosing spondylitis patients and healthy controls. Conclusion: Low frequency of HLA-B27 and clinical variations in ankylosing spondylitis may be due to different genetic and/or environmental factors in Turkey. (C) 2008 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.jbspin.2007.06.021
dc.identifier.endpage302en_US
dc.identifier.issn1297-319X
dc.identifier.issn1778-7254
dc.identifier.issue3en_US
dc.identifier.pmid18424159en_US
dc.identifier.scopus2-s2.0-42749094934en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jbspin.2007.06.021
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8130
dc.identifier.volume75en_US
dc.identifier.wosWOS:000256175200011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.ispartofJOINT BONE SPINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01777
dc.subjectankylosing spondylitisen_US
dc.subjectHLA-B27en_US
dc.subjectHLA-B27 allelesen_US
dc.titleLow frequency of HLA-B27 in ankylosing spondylitis patients from Turkeyen_US
dc.typeArticle
dspace.entity.typePublication

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