Toxicity of cadmium based and cadmium free quantum dots in primary cultured zebrafish hepatocytes

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dc.contributor.authorKaluc, N.
dc.contributor.authorBilgiseven, I.
dc.contributor.authorMutlu, O.
dc.contributor.authorGulsoy, N.
dc.date.accessioned2024-07-12T21:40:03Z
dc.date.available2024-07-12T21:40:03Z
dc.date.issued2020en_US
dc.department[Belirlenecek]en_US
dc.description.abstractQuantum Dots (QDs) are one of the most important nanomaterials in nanotechnology owing to their unique physicochemical properties. A conventional QD contains Cd2+ in its core and in order to reduce its toxicity Cd-core/ZnS-shell and Cd-free QDs were produced. However, ZnS shell was not found as protective as predicted. Also, still not much is known about the toxicity of Cd-free QD. In this paper, we evaluated and compared the cytotoxicity and genotoxicity of three types of QDs (Cd-based core, Cd-based core/shell, and Cd-free QDs) in primary cultured zebrafish hepatocytes. We show that Cd-based QDs significantly decreased cell viability whereas Cd-Free QDs caused a significant increase in cell viability in 24h. Moreover, ZnS shell reduced Cd2+ ion release into the cell but did not effectively prevent the cell from cytotoxic or genotoxic effects of the QD. Although the effects of Cd-based and Cd-Free QDs on cell viability were different, they both induced reactive oxygen species (ROS) production, DNA strand breaks and Rad51 downregulation in primary cultured zebrafish hepatocytes, revealing that they induce oxidative stress in these cells. To the best of our knowledge, this is the first report on the comparative toxicity evaluation of Cd-based with core and core/shell type, Cd-free QDs and CdCF by assessing ROS production, DNA damage and Rad51 expression. © 2020 Parlar Scientific Publications. All rights reserved.en_US
dc.identifier.endpage6110en_US
dc.identifier.issn1018-4619
dc.identifier.issue7Aen_US
dc.identifier.scopus2-s2.0-85091602136en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6102en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7111
dc.identifier.volume29en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherParlar Scientific Publicationsen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04835
dc.subjectCadmiumen_US
dc.subjectCadmium Free Quantum Dotsen_US
dc.subjectCometen_US
dc.subjectRad51en_US
dc.subjectZebrafishen_US
dc.titleToxicity of cadmium based and cadmium free quantum dots in primary cultured zebrafish hepatocytesen_US
dc.typeArticle
dspace.entity.typePublication

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