How does the Exponential Increase in Rocuronium Dose Effect the Train of Four Parameters in Rats Reversed with Sugammadex? An Animal Model

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dc.authoridkose, halil cihan/0000-0003-1550-348Xen_US
dc.authoridGüven Kose, Selin/0000-0003-4293-7814en_US
dc.authoridAYDIN, Serdar Onur/0000-0002-6698-4685en_US
dc.authoridTulgar, serkan/0000-0003-1996-7505en_US
dc.authoridTasargol, Omer/0000-0003-1408-5503en_US
dc.contributor.authorKöse, Halil Cihan
dc.contributor.authorKose, Selin Güven
dc.contributor.authorAydın, Serdar Onur
dc.contributor.authorKuzucuoğlu, Tamer
dc.contributor.authorTasargol, Omer
dc.contributor.authorTulgar, Serkan
dc.date.accessioned2024-07-12T21:37:42Z
dc.date.available2024-07-12T21:37:42Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractBACKGROUND/AIMS: Sugammadex is a gamma cyclodextrin structured agent used for reversing the effect of steroidal neuromuscular blocking (NMB) agents. The first aim of this study was to evaluate the dose of rocuronium required to re-establish NMB when administered 2 min after its reversal with sugammadex in rats. Also, to monitor the onset times and durations of NMB achieved by variable doses of rocuronium after reversal with sugammadex.MATERIALS AND METHODS: Thirty-five Sprague-Dawley rats were randomly divided into groups including control and four experimental groups. The control group was designed to determine the onset time and duration of NMB induced by 1.2 mg/kg rocuronium. In the control group, no sugammadex was applied. In the experimental groups, rocuronium (1.2 mg/kg) was reversed with sugammadex (4 mg/kg). Subsequently, experimental groups were administered various doses of rocuronium. Groups were named according to the rocuronium dose administered (group 2.4, group 3.6, group 4.8 and group 6.0). Rats in all groups were monitored with train of four.RESULTS: In group 2.4, rocuronium did not ensure NMB. In group 3.6, NMB occurredin only 3 rats. All rats in groups 4.8 and 6.0 achieved complete NMB. There was no statistically significant difference in the onset time of NMB in 4.8 and 6.0 groups (p<0.05). The mean duration of NMB in the experimental groups was significantly shorter than that in the control group (p<0.01).CONCLUSION: Sufficient muscle relaxation and intubation conditions could be achieved with 3.6 mg/kg, 4.8 mg/kg, and 6.0 mg/kg doses of rocuronium as short as 2 min after sugammadex.en_US
dc.identifier.doi10.4274/cjms.2021.3347
dc.identifier.endpage233en_US
dc.identifier.issn2149-7893
dc.identifier.issn2536-507X
dc.identifier.issue3en_US
dc.identifier.startpage229en_US
dc.identifier.trdizinid1188931en_US
dc.identifier.urihttps://doi.org/10.4274/cjms.2021.3347
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1188931
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6885
dc.identifier.volume8en_US
dc.identifier.wosWOS:001023048800010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofCyprus Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04227
dc.subjectSugammadexen_US
dc.subjectRocuroniumen_US
dc.subjectNeuromuscular Blocken_US
dc.titleHow does the Exponential Increase in Rocuronium Dose Effect the Train of Four Parameters in Rats Reversed with Sugammadex? An Animal Modelen_US
dc.typeArticle
dspace.entity.typePublication

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