Implementation of a User-Friendly, Flexible Expert System for Selecting Optimal Set of Kidney Exchange Combinations of Patients in a Transplantation Center

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dc.contributor.authorKarademirci, O.
dc.contributor.authorTerzioglu, A. S.
dc.contributor.authorYilmaz, S.
dc.contributor.authorTombus, O.
dc.date.accessioned2024-07-12T21:53:34Z
dc.date.available2024-07-12T21:53:34Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIntroduction. For end-stage renal disease patients, kidney transplantation is the only long-term solution. The number of deceased donors is limited. Living kidney donation is subject to strict regulations, limiting possible donors only to the extended family of the patient for preventing the organ trade. There may be incompatibilities between the patients and their related donors, such as ABO blood type incompatibility, positive cross-match, and so on. Methods. Pairwise exchanges between donors and recipients increase both the quality and the quantity of feasible transplantations. The maximum benefit in kidney exchanges could only be yielded by developing a central kidney exchange program supported by a nation wide living donor pool database. In the absence of a central kidney exchange program, each transplantation center arranges the kidney allocations using spreadsheets manually. Selecting best possible combination of exchanges simultaneously is a difficult task when performed manually. It is a proven NP-Hard combinatorial optimization problem. However, using mixed integer programming methods the best combination can be found in seconds. Results. We developed a user-friendly decision support system that can be used in transplantation centers, facilitating their operations. Conclusions. The decision support system can be modified for according to the matching preferences of transplantation centers and it can be used as a simulation tool for analyzing different allocation methods.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.051
dc.identifier.endpage1264en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid26093694en_US
dc.identifier.scopus2-s2.0-84931332533en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1262en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.transproceed.2015.04.051
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8520
dc.identifier.volume47en_US
dc.identifier.wosWOS:000357066800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofTRANSPLANTATION PROCEEDINGSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03624
dc.titleImplementation of a User-Friendly, Flexible Expert System for Selecting Optimal Set of Kidney Exchange Combinations of Patients in a Transplantation Centeren_US
dc.typeArticle
dspace.entity.typePublication

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