Investigation of low and high dose rate X-ray effects on histopathological changes and prognostic importance of Ki-67 in laryngeal cancer radiotherapy

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dc.authoridERDEM, ESRA/0000-0001-9031-9530en_US
dc.authoridAras, Serhat/0000-0002-4825-5921en_US
dc.contributor.authorAras, Serhat
dc.contributor.authorÖzkanli, Seyma
dc.contributor.authorErdem, Esra
dc.contributor.authorGokalp, Sevtap
dc.contributor.authorErdoğan, Ceren Ezgi
dc.date.accessioned2024-07-12T21:37:31Z
dc.date.available2024-07-12T21:37:31Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractThe aim of this study is to analyze the effect on histopathological changes and Ki-67 expression levels of Flat-tening Filter (FF) and Flattening Filter Free (FFF) beams to investigate the radiobiological mechanisms under-lying laryngeal cancer (LCa) post-radiotherapy (RT) on mice models. Forty adult NOD SCID gamma (NSG) mice models were randomly divided into four groups; the sham, LCa, FF -RT and FFF-RT groups. The head and neck region of mice in FF-RT and FFF-RT groups (LCa plus RT groups) were irradiated with a single dose of 18 Gy at 400 MU/min and 1400 MU/min. The NSG mice received radiotherapy 30 days after tumor transplantation and sacrificed 2 days after radiotherapy for analysis of histopathology pa-rameters and K-67 expression levels. Comparing the LCa, FF-RT and FFF-RT groups with the sham group, statistically significant differences were observed in histopathological parameters depending on tumor tissue and dose rate (p < 0.05). When the his-topathological effects of FF-RT beam on LCa tissue were compared with FFF-RT beam, it was observed that statistically significant differences occurred (p < 0.05). Comparing the LCa group with the sham group, it was observed that the Ki-67 level affected significantly depending on the development of cancer (p < 0.01). It was concluded that FF and FFF beams caused significant changes in the histopathological parameters and Ki -67 expression levels. When the effects of FFF beam on Ki-67 levels, cell nucleus and cytoplasmic findings were compared with FF beam, significant radiobiological differences were observed.en_US
dc.description.sponsorshipScientific Research Projects Grants Unit, University of Health Sciences Turkey [2019/063]en_US
dc.description.sponsorshipFunding This work was supported by the Scientific Research Projects Grants Unit, University of Health Sciences Turkey (2019/063) .en_US
dc.identifier.doi10.1016/j.apradiso.2023.110823
dc.identifier.issn0969-8043
dc.identifier.issn1872-9800
dc.identifier.pmid37116260en_US
dc.identifier.scopus2-s2.0-85153535736en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.apradiso.2023.110823
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6827
dc.identifier.volume197en_US
dc.identifier.wosWOS:000988062500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofApplied Radiation And Isotopesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04169
dc.subjectRadiotherapyen_US
dc.subjectFlattening Filter Freeen_US
dc.subjectLaryngeal Canceren_US
dc.subjectHistopathologyen_US
dc.subjectKi-67en_US
dc.titleInvestigation of low and high dose rate X-ray effects on histopathological changes and prognostic importance of Ki-67 in laryngeal cancer radiotherapyen_US
dc.typeArticle
dspace.entity.typePublication

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