Effects of different cardioplegic solutions on nitric oxide release from coronary vasculature in diabetic patients undergoing coronary artery bypass surgery

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dc.contributor.authorKaraca P.
dc.contributor.authorYurtseven N.
dc.contributor.authorEnç Y.
dc.contributor.authorAksoy T.
dc.contributor.authorSokullu O.
dc.contributor.authorBilgen F.
dc.contributor.authorCanik S.
dc.date.accessioned2024-07-12T21:44:38Z
dc.date.available2024-07-12T21:44:38Z
dc.date.issued2006en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to compare the effects of two different cardioplegic solutions on nitric oxide (NO) release from coronary vasculature in patients with type II diabetes mellitus undergoing coronary artery bypass grafting (CABG) surgery. Methods: Forty patients undergoing elective CABG surgery were randomized to be given crystalloid (Group 1) or blood (Group 2) cardioplegia. Aortic and coronary sinus blood samples were taken at three different time periods and the release of NO from the coronary vasculature was determined by measuring its stable end-products, nitrite and nitrate. The difference between the aortic and coronary sinus concentrations of nitrite and nitrate represents the amount of NO released by coronary vascular bed. Results: Before application of aortic cross-clamp, at T1 period, the levels of nitrite/nitrate from the coronary vasculature were similar in both groups (6.53±1.21 µM vs 6.07±1.24 µM, p> 0.05). However after the removal of cross-clamp, a significant decrease in NO was observed in Group 1 as compared with Group 2 (4.21±0.73 µM vs 4.92±1.02 µM, p< 0.01). This decrease persisted at T3 period, after 30 minutes of reperfusion in group 1 being significantly different from group 2 (3.86±0.49 vs 4.37±0.72 µM, p<0.05). Conclusion: This study has shown that in patients with type II diabetes mellitus crystalloid cardioplegia causes a decrease in the release of NO from coronary vascular bed during aortic cross-clamp and reperfusion period whereas more physiologic blood cardioplegia did not Our findings indicate that blood cardioplegia protects endothelial function better than crystalloid cardioplegia in diabetic patients.en_US
dc.identifier.endpage351en_US
dc.identifier.issn1302-8723
dc.identifier.issue4en_US
dc.identifier.pmid17162282en_US
dc.identifier.scopus2-s2.0-33846397359en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7744
dc.identifier.volume6en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00183
dc.subjectCardiopulmonary bypassen_US
dc.subjectDiabetes mellitusen_US
dc.subjectNitric oxideen_US
dc.titleEffects of different cardioplegic solutions on nitric oxide release from coronary vasculature in diabetic patients undergoing coronary artery bypass surgeryen_US
dc.typeArticle
dspace.entity.typePublication

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