Negative correlation between D-dimer and homocysteine levels during pregnancy and the postpartum period a prospective study

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dc.authorid0000-0002-3166-9052en_US
dc.authorid0000-0001-8682-5027en_US
dc.authorid0000-0002-4627-8628en_US
dc.authorid0000-0003-2802-7793en_US
dc.contributor.authorHaliloglu, Berna
dc.contributor.authorAksungar, Fehime Benli
dc.contributor.authorCelik, Aygen
dc.contributor.authorIlter, Erdin
dc.contributor.authorCoksuer, Hakan
dc.contributor.authorOzekici, Umit
dc.date.accessioned2024-07-12T21:46:36Z
dc.date.available2024-07-12T21:46:36Z
dc.date.issued2010en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective There have been conflicting data about the role of increased levels of homocysteine (Hcy) on haemostatic system We aim to investigate prospectively the relation between serum Hcy levels and changes in haemostatic system in pregnancy and postpartum period Study design Sixty-eight healthy pregnant women were included in the study Blood samples were obtained in the 11th gestational week 25th gestational week 32nd gestational week and postpartum 4th week The haemoglobin levels white blood cell count (WBC) platelet count activated partial thromboplastin time (aPTI-) prothrombin time (PT) fibrinogen D-dimer Hcy vitamin B12 and folate levels were measured Results Serum Hcy levels were negatively correlated with D-dimer levels (r = -0 57 p < 0 0001) The highest levels of D-dimer (1046 62 +/- 322 01 ng/ml) were achieved in the third trimester and the lowest levels of serum Hcy (4 45 +/- 123 mmol/1) were detected in the same trimester In postpartum fourth week D dimer levels were decreased to normal levels (238 27 +/- 198 59 ng/ml) while the serum Hcy levels were reached to the highest levels (7 99 +/- 1 36 mmol/1) Conclusion The negative correlation between Hcy and D-dimer levels may be a compensatory mechanism to maintain the normal haemostatic balance in pregnancy Hence possible advantage of low Hcy levels in pregnancy may be to prevent undesired thrombosis (C) 2010 Elsevier Ireland Ltd All rights reserveden_US
dc.identifier.doi10.1016/j.ejogrb.2010.06.018
dc.identifier.endpage26en_US
dc.identifier.issn0301-2115
dc.identifier.issue1en_US
dc.identifier.pmid20656399en_US
dc.identifier.scopus2-s2.0-77958157495en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejogrb.2010.06.018
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7948
dc.identifier.volume153en_US
dc.identifier.wosWOS:000284298000005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00859
dc.subjectHomocysteineen_US
dc.subjectPregnancyen_US
dc.subjectHaemostasisen_US
dc.subjectD dimeren_US
dc.titleNegative correlation between D-dimer and homocysteine levels during pregnancy and the postpartum period a prospective studyen_US
dc.typeArticle
dspace.entity.typePublication

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