Differences in the cytological features of atypical adenomatous hyperplasia and low-grade prostatic adenocarcinoma

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dc.contributor.authorMidi A.
dc.contributor.authorTecimer T.
dc.contributor.authorBozkurt S.
dc.contributor.authorÖzkan N.
dc.date.accessioned2024-07-12T21:53:53Z
dc.date.available2024-07-12T21:53:53Z
dc.date.issued2010en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to review the histological features and to define parameters distinguishing atypical adenomatous hyperplasia from prostatic adenocarcinoma grade 1 and 2. We evaluated 14 parameters related with cytological properties. Material and Method: We found 11 atypical adenomatous hyperplasia (22 foci) and 15 prostatic adenocarcinoma grade 1 and 2 (22 foci) lesions in 105 radical prostatectomy specimens. Basal cell-specific keratin (34ßE12) was applied and based on the fact that prostatic adenocarcinoma grade 1 and 2 lesions do not have basal cells we grouped the lesions as atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2. Results: Statistically significant differences were found between atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2 lesions for some parameters including the largest nuclear diameter, nuclear location, 1-2 µm nucleolus, > 2 µm nucleolus, and nuclei containing multiple nucleoli. We found similar properties between the two lesions for the following parameters: irregularity of nuclear membrane, median diameter of the nucleolus, chromatin pattern, pynotic nucleus, nuclear pleomorphism, < 1 µm nucleolus, nucleolar margination, and the ratio of nucleus to cytoplasm and the appearance of cytoplasm in the secretory cells. Conclusion: Evaluation of the overall histomorphological criteria is important in the differentiation of atypical adenomatous hyperplasia and prostatic adenocarcinoma grade 1 and 2 lesions.en_US
dc.identifier.doi10.5146/tjpath.2010.01025
dc.identifier.endpage208en_US
dc.identifier.issn1018-5615
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-77957322173en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage200en_US
dc.identifier.trdizinid105422en_US
dc.identifier.urihttps://dx.doi.org/10.5146/tjpath.2010.01025
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8548
dc.identifier.volume26en_US
dc.identifier.wosWOS:000217434700005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofTurk Patoloji Dergisi/Turkish Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03668
dc.subjectAdenocarcinomaen_US
dc.subjectHyperplasiaen_US
dc.subjectProstateen_US
dc.titleDifferences in the cytological features of atypical adenomatous hyperplasia and low-grade prostatic adenocarcinomaen_US
dc.typeArticle
dspace.entity.typePublication

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