The Relationship Between Prognostic and Organ Failure Scoring Systems Such as APACHE II, SAPS II, MODS, SOFA and GCS and Quantitative Amino Acid Levels in Intensive Care Unit Patients

Basit Öğe Kaydı
dc.authoridEKER, PINAR/0000-0001-6514-8047en_US
dc.authoridozdil, kamil/0000-0003-2556-3064en_US
dc.authoridDUYGU, AYDIN/0000-0003-4952-537Xen_US
dc.authoridSivritepe, Ridvan/0000-0003-0547-1883en_US
dc.contributor.authorBasat, Sema Uçak
dc.contributor.authorSivritepe, Ridvan
dc.contributor.authorBasat, Okcan
dc.contributor.authorBaygul, Arzu
dc.contributor.authorDuygu, Aydın
dc.contributor.authorEker, Pınar
dc.contributor.authorÖzdil, Kamil
dc.date.accessioned2024-07-12T21:37:30Z
dc.date.available2024-07-12T21:37:30Z
dc.date.issued2021en_US
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: This study aimed to investigate the relationship between the prognostic and organ failure scoring systems and quantitative amino acid levels in patients in the intensive care unit (ICU). Methods: A total of 45 patients over 45 years old, who were admitted to the ICU, were included in the study. Physical examinations of all patients were performed, and blood tests (including serum amino acids) were analyzed. Sequential organ failure assessment (SOFA), multiple organ dysfunction score (MODS), simplified acute physiology score II (SAPS II), acute physiology and chronic health evaluation II (APACHE II), and glasgow coma scale (GCS) scores of patients were calculated. Risk ratios were determined according to the mortality and organ failure scores of patients, and patients were grouped as high-risk and low risk. All these parameters were compared between these groups, and the relationship between amino acid levels and risk scores was evaluated. Statistical significance level was determined as a p-value of <0.05. Results: This study was carried out on 45 patients, 23 females and 22 males. The mean age of the patients was 74 +/- 11 years. In high-risk patients compared to low-risk group; methionine, ornithine, and phenylalanine levels according to APACHE II; beta-alanine, cystine, 3-methyl histidine, phenylalanine, and proline levels according to SAPS II; alanine, beta-alanine, phenylalanine, glycine, histidine, methionine, and ornithine levels according to GCS were significant different (p<0.05 for all). We found a significant positive correlation between the APACHE II score and beta alanine (r=0.466; p=0.001), citrulline (r=0.394; p=0.007), ethanolamine (r=0.366; p=0.013), histidine (r=0.353; p=0.017), 3-methyl histidine (r=0.450; p=0.002), ornithine (r=0.445; p=0.002), phenylalanine (r=0.548; p<0.001). There was a significant positive correlation between the SAPS II score and beta alanine (r=0.403; p=0.006), cystathionine (r=0.341; p=0.022), ethanolamine (r=0.356; p=0.017), 3-methyl histidine (r=0.402; p=0.006), ornithine (r=0.349; p=0.019), phenylalanine (r=0.525; p<0.001) and between the MODS score and alanine (r=0.340; p=0.022), beta alanine (r=0.407; p=0.006), cystathionine (r=0.352; p=0.018), ethanolamine (r=0.358; p=0.0169), histidine (r=0.495; p=0.001), 3-methyl histidine (r=0.407; p=0.006), methionine (r=0.462; p=0.001), ornithine (r=0.360; p=0.015), phenylalanine (r=0.621; p<0.001), proline (r=0.445; p=0.002). We found a significant positive correlation between the SOFA score and alanine (r=0.547; p<0.0019), beta-alanine (r=0.354; p=0.0179), arginine (r=0.423; p=0.004), cystathionine (r=0.423; p=0.004), ethanolamine (r=0.437; p=0.003), glycine (r=0.399; p=0.007), histidine (r=0.512; p<0.001), 3-methyl histidine (r=0.327; p=0.028), leucine (r=0.376; p=0.011), methionine (r=0.585; p<0.001), ornithine (r=0.467; p=0.001), phenylalanine (r=0.644; p<0.001), proline (r=0.523; p<0.001), threonine (r=0.371; p=0.012). Also, there was a significant negative correlation between GCS score and beta alanine (r=-0.390; p=0.008), ethanolamine (r=-0.364; p=0.014), glycine (r=-0.360; p=0.015), ornithine (r=-0.510; p=0.000), phenylalanine (r=-0.433; p=0.003). Conclusion: This study found significantly higher methionine, ornithine, phenylalanine, beta-alanine, cystine, 3-methyl histidine, proline, alanine, glycine, and histidine levels in patients with high-risk scores.en_US
dc.identifier.doi10.4274/BMJ.galenos.2021.78790
dc.identifier.endpage342en_US
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85122502802en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage334en_US
dc.identifier.trdizinid506749en_US
dc.identifier.urihttps://doi.org/10.4274/BMJ.galenos.2021.78790
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/506749
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6821
dc.identifier.volume17en_US
dc.identifier.wosWOS:000735123100009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofMedical Journal of Bakirkoyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04163
dc.subjectAmino Acidsen_US
dc.subjectIntensive Care Unitsen_US
dc.subjectPrognosisen_US
dc.subjectRisk Factorsen_US
dc.subjectApacheen_US
dc.subjectSimplified Acute Physiology Scoreen_US
dc.subjectOrgan Dysfunction Scoresen_US
dc.titleThe Relationship Between Prognostic and Organ Failure Scoring Systems Such as APACHE II, SAPS II, MODS, SOFA and GCS and Quantitative Amino Acid Levels in Intensive Care Unit Patientsen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu