Ratios of homocysteine and nitrite to high-density lipoprotein in coronary artery patients with the different degree of stenosis

Küçük Resim Yok

Tarih

2004

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

ELSEVIER SCIENCE INC

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Araştırma projeleri

Organizasyon Birimleri

Dergi sayısı

Özet

Although the interaction between Hcy, NO2- and vascular disease has been extensively studied, there are no data verifying their ratios to HDL-C in coronary artery disease (CAD). We examined whether Hcy/HDL-C and NO2-/HDL-C ratios correlated with the degree of stenosis in CAD. Also, TC/HDL-C and LDL-C/HDL-C ratios were evaluated in the same individuals. Seventy subjects were divided into three groups according to coronary angiography findings: >50% stenosis (n=35, years: 50.9+/-3.4; Group 1), 5-50% stenosis (n=20, years: 50.6+/-3.8; Group 2), <5% narrowing (n=15, years: 49.0+/-3.2; control group). Hcy/HDL-C, NO2-/HDL-C, TC/HDL-C and LDL-C/HDL-C were statistically higher in both Group 1 patients (p=0.001, for all ratios) and Group 2 patients (p=0.001, p=0.001, p=0.03, 0.041, respectively) with respect to controls. The values were correlated with the degree of stenosis in the different significance levels (r=0.496, p=0.001; r=0.384, p=0.004; r=0.334, p=0.012; r=0.321, p=0.016, respectively). In patients with >50% stenosis, NO2-/HDL-C was only shown to change significantly in relation to obstructive artery number (p=0.026) and also showed a positive correlation (r=0.379, p=0.032). In conclusion, Hcy/HDL-C and NO2-/HDL-C appear to be more indicative than TC/HDL-C and LDL-C/HDL-C in the evaluation of CAD patients regarding the degree of stenosis. However, only NO2-/HDL evaluation seems to be a reliable indicator in the patients with heavy stenosis of CAD. Further studies are needed to confirm the results of present study. (C) 2004 Elsevier Inc. All rights reserved.

Açıklama

Anahtar Kelimeler

cholesterol, coronary artery disease, homocysteine, nitrite, ratio

Kaynak

VASCULAR PHARMACOLOGY

WoS Q Değeri

Q2

Scopus Q Değeri

Q1

Cilt

41

Sayı

3

Künye