Ratios of homocysteine and nitrite to high-density lipoprotein in coronary artery patients with the different degree of stenosis

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dc.contributor.authorAfrasyap, L
dc.contributor.authorOzturk, G
dc.date.accessioned2024-07-12T21:57:08Z
dc.date.available2024-07-12T21:57:08Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAlthough the interaction between Hcy, NO2- and vascular disease has been extensively studied, there are no data verifying their ratios to HDL-C in coronary artery disease (CAD). We examined whether Hcy/HDL-C and NO2-/HDL-C ratios correlated with the degree of stenosis in CAD. Also, TC/HDL-C and LDL-C/HDL-C ratios were evaluated in the same individuals. Seventy subjects were divided into three groups according to coronary angiography findings: >50% stenosis (n=35, years: 50.9+/-3.4; Group 1), 5-50% stenosis (n=20, years: 50.6+/-3.8; Group 2), <5% narrowing (n=15, years: 49.0+/-3.2; control group). Hcy/HDL-C, NO2-/HDL-C, TC/HDL-C and LDL-C/HDL-C were statistically higher in both Group 1 patients (p=0.001, for all ratios) and Group 2 patients (p=0.001, p=0.001, p=0.03, 0.041, respectively) with respect to controls. The values were correlated with the degree of stenosis in the different significance levels (r=0.496, p=0.001; r=0.384, p=0.004; r=0.334, p=0.012; r=0.321, p=0.016, respectively). In patients with >50% stenosis, NO2-/HDL-C was only shown to change significantly in relation to obstructive artery number (p=0.026) and also showed a positive correlation (r=0.379, p=0.032). In conclusion, Hcy/HDL-C and NO2-/HDL-C appear to be more indicative than TC/HDL-C and LDL-C/HDL-C in the evaluation of CAD patients regarding the degree of stenosis. However, only NO2-/HDL evaluation seems to be a reliable indicator in the patients with heavy stenosis of CAD. Further studies are needed to confirm the results of present study. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.vph.2004.07.002
dc.identifier.endpage96en_US
dc.identifier.issn1537-1891
dc.identifier.issn1879-3649
dc.identifier.issue3en_US
dc.identifier.pmid15380734en_US
dc.identifier.scopus2-s2.0-4544326234en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.vph.2004.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8646
dc.identifier.volume41en_US
dc.identifier.wosWOS:000224447000002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofVASCULAR PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04013
dc.subjectcholesterolen_US
dc.subjectcoronary artery diseaseen_US
dc.subjecthomocysteineen_US
dc.subjectnitriteen_US
dc.subjectratioen_US
dc.titleRatios of homocysteine and nitrite to high-density lipoprotein in coronary artery patients with the different degree of stenosisen_US
dc.typeArticle
dspace.entity.typePublication

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