Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats

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dc.authoridŞener Akçora, Dila/0000-0001-9496-7324en_US
dc.authoridkaradağ, mehmet/0000-0001-9539-4193en_US
dc.authoridDeveci, Uğur/0000-0003-4449-1190en_US
dc.authoridKocak, Mihrican/0000-0003-0106-6602en_US
dc.contributor.authorŞener, Dila
dc.contributor.authorKocak, Mihrican
dc.contributor.authorSaracoğlu, Ramazan
dc.contributor.authorDeveci, Uğur
dc.contributor.authorKaradag, Mehmet
dc.date.accessioned2024-07-12T21:37:56Z
dc.date.available2024-07-12T21:37:56Z
dc.date.issued2022en_US
dc.department[Belirlenecek]en_US
dc.description.abstractBackground and Aim: In this study, we aimed to assess the hemostatic and histopathological impacts of the Algan hemostatic agent (AHA) with the liver injury model. Materials and Methods: 24 male rats, 10-12 week old, were randomly divided into three equal groups (n=8) as control (physiological saline solution), AHA liquid and AHA powder. A total of three iatrogenic cut injuries were performed on the anterior surface of the left liver lobe. After bleeding started, sponges soaked with physiological saline, AHA liquid, AHA powder were gently pressed on the injured area for 20 seconds in corresponding groups, respectively. The bleeding time was measured with a timer. Failure to stop bleeding after three consecutive applications was considered as a failure. Animals were euthanized at the tenth minute of the procedure. Left liver lobes were removed for histopathological examination. Results: Bleeding control success rates of AHA liquid were significantly higher than that of the AHA powder group, and both forms were more effective than physiological saline. A superficial thick granulation tissue with entrapped powder residual materials was detected in the AHA powder group. Liver parenchyma was intact in liquid and powder groups. Conclusion: AHA is a fast-acting and applicable hemostatic agent in the liver bleeding model. However, further comparative studies in various organs are needed.en_US
dc.identifier.doi10.14744/hf.2021.2021.0040
dc.identifier.endpage20en_US
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue1en_US
dc.identifier.pmid35782368en_US
dc.identifier.scopus2-s2.0-85164368002en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage16en_US
dc.identifier.trdizinid1170037en_US
dc.identifier.urihttps://doi.org/10.14744/hf.2021.2021.0040
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1170037
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6969
dc.identifier.volume3en_US
dc.identifier.wosWOS:000863555800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofHepatology Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04311
dc.subjectAlgan Hemostatic Agenten_US
dc.subjectInjuryen_US
dc.subjectTraumaen_US
dc.subjectLiveren_US
dc.subjectRaten_US
dc.titleHistopathological effects of Algan hemostatic agent (AHA) in liver injury model in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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